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Bethyl Laboratories
Cul3 Polyclonal Antibody
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Product Details
A301-109A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 650 and 700 of human cullin 3.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Rat, X. laevis and X. tropicalis
Target Information
Cullin 3 is a member of the family of human cullin genes (CUL 1, 2, 3, 4a, 4b, and 5) homologous to the S. cerevisiae cdc 53 gene. CUL 1 forms a complex with human p19 skp1 and F box protein p45 skp2. Together with cdc 53 (Known as Cul A), as three subunits, they form a ubiquitin ligase-controlling proteolysis of G1 cell cycle regulatory proteins. In contrast to CUL 1, CUL 2 does not associate with p19 skp1 and p45 skp2. Instead, CUL 2 forms a complex with an inactive transcriptional elongation complex, SIII, formed by three subunits: Elongain C, Elongin B and VHL. The function of this association remains unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CUL-3; Cullin-3; OTTHUMP00000203839; OTTHUMP00000203840; unnamed protein product
Gene Aliases: AI467304; AW146203; CUL-3; CUL3; KIAA0617; mKIAA0617; NEDAUS; PHA2E
UniProt ID: (Human) Q13618, (Mouse) Q9JLV5
Entrez Gene ID: (Human) 8452, (Mouse) 26554
ubiquitin-protein transferase activity
Notch binding
protein binding
cyclin binding
POZ domain binding
ubiquitin protein ligase binding
identical protein binding
ubiquitin protein ligase activity
ubiquitin ligase complex scaffold activity
protein homodimerization activity
protein heterodimerization activity
ubiquitin-protein ligase
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
protein polyubiquitination
mitotic cell cycle
cell morphogenesis
in utero embryonic development
kidney development
trophectodermal cellular morphogenesis
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
protein monoubiquitination
misfolded or incompletely synthesized protein catabolic process
ER to Golgi vesicle-mediated transport
apoptotic process
response to stress
inflammatory response
response to oxidative stress
mitotic metaphase plate congression
signal transduction
integrin-mediated signaling pathway
gastrulation
positive regulation of cell proliferation
gene expression
regulation of gene expression
negative regulation of macromolecule biosynthetic process
Wnt signaling pathway
vesicle-mediated transport
cell migration
protein ubiquitination
stem cell division
cell projection organization
protein catabolic process
anaphase-promoting complex-dependent catabolic process
positive regulation of protein ubiquitination
protein destabilization
cellular response to nutrient levels
positive regulation of cytokinesis
negative regulation of type I interferon production
positive regulation of type I interferon production
cellular response to insulin stimulus
cellular response to amino acid starvation
cellular response to oxidative stress
negative regulation of Rho protein signal transduction
embryonic cleavage
stress fiber assembly
proteasome-mediated ubiquitin-dependent protein catabolic process
fibroblast apoptotic process
positive regulation of mitotic metaphase/anaphase transition
COPII vesicle coating
cell division
protein autoubiquitination
type I interferon signaling pathway
renal sodium ion absorption
protein K48-linked ubiquitination
cellular response to amino acid stimulus
nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
liver morphogenesis
regulation of primary metabolic process
intrinsic apoptotic signaling pathway
regulation protein catabolic process at postsynapse
RNA polymerase II transcription initiation surveillance
regulation of cellular response to insulin stimulus
positive regulation of mitotic cell cycle phase transition
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
transport
negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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