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Bethyl Laboratories

NCoR Polyclonal Antibody

View all (7) NCoR1 antibodies

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NCoR Polyclonal Antibody

Product Details

A301-145A

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:10,000
-

Immunoprecipitation (IP)

2-10 µg/mg lysate
-

ChIP-sequencing (ChIP-Seq)

2 µg
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 1525 and 1575 of human nuclear receptor co-repressor 1.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.20 mg/mL

Amount

20 µg

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.0 to 8.0, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: h KIAA1047; hCIT529I10; MGC104216; N-CoR; N-CoR1; nrcr; nuclear receptor corepressor; Nuclear receptor corepressor 1; protein phosphatase 1, regulatory subunit 109; retinoid X receptor interacting protein 13; retinoid X receptor-interacting protein 13; thyroid hormone- and retinoic acid receptor-associated corepressor 1; unnamed protein product

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Gene Aliases: 5730405M06Rik; A230020K14Rik; hN-CoR; KIAA1047; mKIAA1047; N-CoR; N-CoR1; NCOR1; PPP1R109; RIP13; Rxrip13; TRAC1

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UniProt ID: (Human) O75376

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Entrez Gene ID: (Human) 9611, (Mouse) 20185

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Function(s)
transcription regulatory region sequence-specific DNA binding DNA binding transcription corepressor activity protein binding ligand-dependent nuclear receptor binding histone deacetylase binding thyroid hormone receptor binding RNA polymerase II sequence-specific DNA binding transcription factor binding RNA polymerase II regulatory region DNA binding RNA polymerase II activating transcription factor binding chromatin binding transcription factor activity, sequence-specific DNA binding protein domain specific binding estrogen receptor binding histone deacetylase regulator activity nuclear hormone receptor binding retinoic acid receptor binding peroxisome proliferator activated receptor binding sequence-specific DNA binding transcription regulatory region DNA binding retinoid X receptor binding chromatin/chromatin-binding, or -regulatory protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter chromatin organization regulation of cellular ketone metabolic process locomotor rhythm negative regulation of glycolytic process negative regulation of transcription, DNA-templated negative regulation of fatty acid metabolic process negative regulation of JNK cascade rhythmic process spindle assembly negative regulation of androgen receptor signaling pathway negative regulation of pri-miRNA transcription from RNA polymerase II promoter CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of cell proliferation negative regulation of gene expression negative regulation of phosphatidylinositol 3-kinase signaling chromatin modification thalamus development regulation of histone deacetylation positive regulation of histone deacetylation circadian regulation of gene expression regulation of multicellular organism growth cholesterol homeostasis regulation of catalytic activity definitive erythrocyte differentiation regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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