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Bethyl Laboratories
CHD7 Polyclonal Antibody
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FIGURE: 1 / 2
CHD7 Antibody (A301-223A) in WB
Detection of human CHD7 by western blot. Samples: Whole cell lysate (50 µg) from HeLa and HEK293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-CHD7 antibody (Product # A301-223A) (lot A301-223A-3) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A301-223A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 2947 and 2997 of human chromodomain helicase DNA binding protein 7.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Chromodomain helicase DNA binding protein 7 (CHD7) is a gene located on chromosome 8q12.2 that encodes a member of the chromodomain helicase DNA-binding (CHD) family, which plays a pivotal role in chromatin remodeling and gene expression regulation. CHD7 contains multiple domains that facilitate its involvement in modifying chromatin structure, thereby influencing the accessibility of DNA for transcription factors and other regulatory proteins. The protein is integral to various developmental processes, including neural crest formation, thus affecting tissues such as the nervous system, skeletal structures, and sensory organs. Mutations in CHD7 are associated with CHARGE syndrome, a multisystem disorder characterized by congenital anomalies including coloboma, heart defects, and ear abnormalities. CHD7's role in chromatin dynamics makes it crucial for normal embryonic development and cellular differentiation. Ongoing research is focused on uncovering CHD7's broader implications in developmental biology and its potential as a therapeutic target in chromatin-related disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent chromatin remodeler CHD7; ATP-dependent helicase CHD7; CHARGE association; CHD-7; Chromo domain-containing protein 7; unnamed protein product
Gene Aliases: CHD7; CRG; HH5; IS3; KAL5; KIAA1416
UniProt ID: (Human) Q9P2D1
Entrez Gene ID: (Human) 55636
skeletal system development
blood vessel development
in utero embryonic development
blood vessel remodeling
heart morphogenesis
ventricular trabecula myocardium morphogenesis
right ventricular compact myocardium morphogenesis
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
rRNA processing
transcription from RNA polymerase II promoter
central nervous system development
adult heart development
sensory perception of sound
locomotory behavior
adult walking behavior
blood circulation
response to bacterium
regulation of gene expression
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
cranial nerve development
olfactory nerve development
olfactory bulb development
T cell differentiation
female genitalia development
embryonic hindlimb morphogenesis
aorta development
aorta morphogenesis
atrioventricular canal development
positive regulation of multicellular organism growth
olfactory behavior
ear morphogenesis
inner ear morphogenesis
chordate embryonic development
camera-type eye development
nose development
positive regulation of transcription from RNA polymerase II promoter
semicircular canal morphogenesis
tissue remodeling
genitalia development
artery morphogenesis
regulation of neurogenesis
neurological system process
cognition
regulation of transport
palate development
retina development in camera-type eye
regulation of growth hormone secretion
limb development
head development
face development
innervation
cardiac septum morphogenesis
epithelium development
secondary palate development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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