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Bethyl Laboratories
EPS15 Polyclonal Antibody
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Product Details
A301-732A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 575 and 625 of human epidermal growth factor receptor pathway substrate 15.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
EPS15 is a ubiquitously expressed protein that is involved in cell growth regulation and may be involved in the regulation of mitogenic signals and control of cell proliferation. Phosphorylation of EPS15 on Tyrosine 849 upon DNA damage is involved in the internalization of EGFR. A chromosomal aberration involving EPS15 is also found in acute leukemias, resulting in a rogue activator protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: accessory endocytosis protein; AF-1p; AF-1p protein; ALL1 fused gene from chromosome 1; Epidermal growth factor receptor substrate 15; Protein AF-1p; Protein Eps15; unnamed protein product
Gene Aliases: AF-1P; AF1P; EPS15; MLLT5
UniProt ID: (Human) P42566
Entrez Gene ID: (Human) 2060
positive regulation of receptor recycling
Golgi to endosome transport
endocytosis
protein transport
vesicle organization
endosomal transport
receptor-mediated endocytosis of virus by host cell
endocytic recycling
regulation of protein localization
regulation of cell proliferation
viral entry into host cell
clathrin coat assembly
ubiquitin-dependent endocytosis
postsynaptic neurotransmitter receptor internalization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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