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Bethyl Laboratories
BTBD12 Polyclonal Antibody
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FIGURE: 1 / 1
BTBD12 Antibody (A302-269A) in IP
Detection of human BTBD12 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg per IP; 10% of IP loaded) from HeLa cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-BTBD12 antibody (Product # A302-269A) (lot 3) used for IP at 6 µg per reaction. BTBD12 was also immunoprecipitated by a previous lot of this antibody (Product # A302-269A) (lot 2) and a second antibody against a different epitope of BTBD12 (A302-270A). For blotting immunoprecipitated BTBD12, A302-270A was used at 1 µg/mL. Detec... View More
Product Details
A302-269A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1650 and 1700 of human BTB (POZ) domain containing 12.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BTB/POZ domain-containing protein 12; Structure-specific endonuclease subunit SLX4
Gene Aliases: BTBD12; FANCP; KIAA1784; KIAA1987; MUS312; SLX4
UniProt ID: (Human) Q8IY92
Entrez Gene ID: (Human) 84464
resolution of meiotic recombination intermediates
double-strand break repair via homologous recombination
DNA replication
DNA repair
nucleotide-excision repair
DNA recombination
cellular response to DNA damage stimulus
DNA double-strand break processing involved in repair via single-strand annealing
positive regulation of telomere maintenance
telomeric D-loop disassembly
response to intra-S DNA damage checkpoint signaling
t-circle formation
negative regulation of telomere maintenance via telomere lengthening
positive regulation of t-circle formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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