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Bethyl Laboratories

A20 Polyclonal Antibody

View all (28) TNFAIP3 antibodies

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A20 Polyclonal Antibody

Product Details

A302-633A

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:10,000
-

Immunoprecipitation (IP)

2-5 µg/mg lysate
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 525 and 575 of human zinc finger protein A20.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

tris citrate/phosphate, pH 7-8

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: OTU domain-containing protein 7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha-induced protein 3; TNFAIP3 (A20); Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; unnamed protein product; Zinc finger protein A20

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Gene Aliases: A20; AIFBL1; AISBL; OTUD7C; TNFA1P2; TNFAIP3

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UniProt ID: (Human) P21580

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Entrez Gene ID: (Human) 7128

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Function(s)
protease binding DNA binding catalytic activity ubiquitin-protein transferase activity thiol-dependent ubiquitin-specific protease activity protein binding peptidase activity cysteine-type peptidase activity zinc ion binding transferase activity hydrolase activity enzyme binding kinase binding identical protein binding ubiquitin binding metal ion binding Lys63-specific deubiquitinase activity K63-linked polyubiquitin binding
Process(es)
B-1 B cell homeostasis response to molecule of bacterial origin immune system process regulation of germinal center formation negative regulation of chronic inflammatory response proteolysis apoptotic process inflammatory response cytoskeleton organization regulation of tumor necrosis factor-mediated signaling pathway cell migration protein deubiquitination positive regulation of Wnt signaling pathway negative regulation of protein ubiquitination response to muramyl dipeptide negative regulation of interleukin-1 beta production negative regulation of interleukin-2 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 3 signaling pathway negative regulation of toll-like receptor 4 signaling pathway negative regulation of toll-like receptor 5 signaling pathway protein K11-linked deubiquitination nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway regulation of cell proliferation negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein catabolic process negative regulation of bone resorption negative regulation of innate immune response negative regulation of smooth muscle cell proliferation regulation of defense response to virus by host negative regulation of inflammatory response negative regulation of B cell activation regulation of vascular wound healing cellular response to hydrogen peroxide negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway protein K63-linked deubiquitination protein K48-linked ubiquitination protein K48-linked deubiquitination cellular response to lipopolysaccharide protein deubiquitination involved in ubiquitin-dependent protein catabolic process tolerance induction to lipopolysaccharide establishment of protein localization to vacuole negative regulation of osteoclast proliferation cellular response to oxygen-containing compound negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of hepatocyte proliferation negative regulation of CD40 signaling pathway negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway
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