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Bethyl Laboratories

YY1 Polyclonal Antibody

View all (36) YY1 antibodies

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YY1 Polyclonal Antibody

Product Details

A302-779A

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:10,000
-

Immunohistochemistry (IHC)

1:100-1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

Immunoprecipitation (IP)

2-5 µg/mg lysate
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 50 and 100 of Human Yin and Yang 1 Protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.20 mg/mL

Amount

20 µg

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.0 to 8.0, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Target Information

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Delta transcription factor; INO80 complex subunit S; NF-E1; Transcriptional repressor protein YY1; UCR-motif DNA-binding protein; UCRBP transcription factor; Yin and yang 1; Yin and Yang 1 protein; Yin Yang 1; YY-1

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Gene Aliases: AW488674; DELTA; GADEVS; INO80S; NF-E1; UCRBP; YIN-YANG-1; YY1

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UniProt ID: (Human) P25490, (Mouse) Q00899

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Entrez Gene ID: (Human) 7528, (Mouse) 22632

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Function(s)
four-way junction DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA binding protein binding zinc ion binding sequence-specific DNA binding SMAD binding metal ion binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding enhancer sequence-specific DNA binding nucleic acid binding histone deacetylase binding transcription regulatory region DNA binding C2H2 zinc finger transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter telomere maintenance double-strand break repair via homologous recombination regulation of DNA replication DNA repair regulation of DNA repair DNA recombination chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter RNA localization cellular response to DNA damage stimulus spermatogenesis anterior/posterior pattern specification response to UV-C gene expression positive regulation of gene expression negative regulation of gene expression hemopoiesis cell differentiation B cell differentiation negative regulation of interferon-beta production regulation of chromosome organization cellular response to UV response to prostaglandin F positive regulation of DNA repair positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development camera-type eye morphogenesis chromosome organization regulation of cell cycle regulation of DNA strand elongation negative regulation of cell growth involved in cardiac muscle cell development cellular response to interleukin-1 immunoglobulin heavy chain V-D-J recombination negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of telomere maintenance in response to DNA damage transcription, DNA-templated transcription from RNA polymerase II promoter
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