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Bethyl Laboratories
TRA2B/SFRS10 Polyclonal Antibody
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FIGURE: 1 / 2
TRA2B/SFRS10 Antibody (A305-011A) in WB
Detection of human and mouse TRA2B/SFRS10 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-TRA2B/SFRS10 antibody (Product # A305-011A) (lot A305-011A-1) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A305-011A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1 to 50 of Human Transformer-2 protein homolog beta.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine
Target Information
SRSF10 (Serine and Arginine Rich Splicing Factor 10) is a member of the SR family of RNA-binding proteins that regulates alternative pre-mRNA splicing. It contains an RNA recognition motif (RRM) and a serine/arginine-rich (RS) domain that mediates RNA binding and protein-protein interactions within the spliceosome. SRSF10 functions as a context-dependent splicing regulator, capable of promoting or repressing exon inclusion depending on cellular conditions. Notably, it undergoes phosphorylation-dependent regulation, and during cellular stress or mitosis it can shift from an activator to a repressor of splicing. SRSF10 has been implicated in cell cycle control, apoptosis, metabolic regulation, and cancer-associated splicing alterations. Formerly known as FUSIP1 (FUS-interacting protein 1), SRSF10 is widely studied for its role in dynamic and stress-responsive RNA processing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 40 kDa SR-repressor protein; contains RNP1 and RNP2 motifs; RS domain; FUS interacting protein (serine-arginine rich) 1; Fus-associated protein with serine-arginine repeats; FUS-interacting protein (serine-arginine rich) 2; FUS-interacting serine-arginine-rich protein 1; FUSIP1; Neural-salient serine/arginine-rich protein; neural-salient SR protein; Neural-specific SR protein; protein phosphatase 1, regulatory subunit 149; serine-arginine repressor protein (40 kDa); Serine/arginine-rich splicing factor 10; serine/arginine-rich splicing factor 13A; SFRS10; splicing factor; Splicing factor SRp38; splicing factor, arginine/serine-rich 13; Splicing factor, arginine/serine-rich 13A; SR protein; SR splicing factor 10; SRrp40; TASR; TLS-associated protein TASR; TLS-associated protein with Ser-Arg repeats; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated serine-arginine protein 1; TLS-associated serine-arginine protein 2; TLS-associated SR protein; unnamed protein product
Gene Aliases: FUSIP1; FUSIP2; NSSR; NSSR1; NSSR2; PPP1R149; SFRS13; SFRS13A; SRp38; SRrp40; SRSF10; Srsf13a; TASR; TASR1; TASR2
UniProt ID: (Human) O75494, (Mouse) Q9R0U0
Entrez Gene ID: (Human) 10772, (Mouse) 14105
spliceosomal tri-snRNP complex assembly
RNA splicing, via transesterification reactions
regulation of alternative mRNA splicing, via spliceosome
mRNA splicing, via spliceosome
regulation of transcription, DNA-templated
mRNA splice site selection
mRNA processing
RNA splicing
cytosolic transport
regulation of mRNA splicing, via spliceosome
negative regulation of mRNA splicing, via spliceosome
mRNA export from nucleus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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