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Invitrogen

TSC2 Monoclonal Antibody (75R23)

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Product Details

AHO1422

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG, kappa

Class

Monoclonal

Type

Antibody

Clone

75R23

Immunogen

Recombinant fragment of human Tuberin expressed in E. coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

purified

Storage buffer

PBS with 1% BSA

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2536339

Target Information

TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2), is implicated as a tumor suppressor and may function in vesicular transport, play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Phosphorylation of tuberin on Ser 939 and Thr 1462 regulates its interaction with hamartin, and is stimulated by various growth factors through the phosphoinositide 3-kinase/Akt pathway. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. TSC2 specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors and are involved in diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma. Alternative splicing results in transcript variants of three different isoforms of TSC2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: OTTHUMP00000198394; protein phosphatase 1, regulatory subunit 160; renal carcinoma; Tsc2; Tuberin; tuberous sclerosis 2 homolog protein; Tuberous sclerosis 2 protein; Tuberous sclerosis 2 protein homolog; tuberous sclerosis complex locus 2; unnamed protein product

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Gene Aliases: LAM; Nafld; PPP1R160; Rc; Tcs2; TSC2; TSC4

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UniProt ID: (Human) P49815, (Rat) P49816

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Entrez Gene ID: (Human) 7249, (Rat) 24855, (Mouse) 22084

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Function(s)
GTPase activator activity protein binding phosphatase binding small GTPase binding protein homodimerization activity Hsp90 protein binding protein heterodimerization activity 14-3-3 protein binding GTPase-activating protein
Process(es)
neural tube closure cytoplasmic translation protein import into nucleus endocytosis heart development protein localization negative regulation of cell proliferation cellular response to starvation vesicle-mediated transport positive regulation of macroautophagy regulation of macroautophagy regulation of endocytosis negative regulation of Wnt signaling pathway cellular response to nutrient levels negative regulation of TOR signaling TORC1 signaling anoikis negative regulation of translational initiation positive regulation of translational initiation regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway positive chemotaxis regulation of small GTPase mediated signal transduction regulation of cell cycle negative regulation of protein kinase B signaling negative regulation of macromitophagy negative regulation of TORC1 signaling positive regulation of TORC1 signaling response to hypoxia negative regulation of protein kinase activity acute-phase response signal transduction phosphatidylinositol 3-kinase signaling negative regulation of phosphatidylinositol 3-kinase signaling cell projection organization cellular response to insulin stimulus negative regulation of MAP kinase activity protein kinase B signaling positive regulation of GTPase activity protein transport into plasma membrane raft establishment of protein localization negative regulation of cell size positive regulation of transcription from RNA polymerase II promoter glucose import insulin-like growth factor receptor signaling pathway negative regulation of epithelial cell proliferation protein homooligomerization protein heterooligomerization
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