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Invitrogen
Aggrecan Monoclonal Antibody (969D4D11)
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FIGURE: 1 / 9
Aggrecan Antibody (AHP0022) in ICC/IF
Regenerative biomaterials 2020 -
Figure 1 Immunophenotypic and morphological features of MSCs and chondrocytes in direct co-culture. (A) Immunohistochemical staining of type I, II, X collagen and aggrecan in MSCs/chondrocytes after 17 days of differentiation in direct 2D and 3D co-culture model (EnVision technique, scale bar = 50 um); (B) Chondrocytes and (G) direct co-culture on culture flask (inverted phase contrast microscope, scale bar... View More
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.jpg?time=20240507?time=20240507 "Aggrecan Antibody (AHP0022) in IHC (P)")
.jpg?time=20240507?time=20240507 "Aggrecan Antibody (AHP0022) in IHC (P)")
Product Details
AHP0022
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Bovine,
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
969D4D11
Immunogen
Human natural aggrecan (proteoglycan), purified from human articular cartilage.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
500 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.5mg/mL sodium azide
Storage conditions
4°C
Shipping conditions
Wet ice
RRID
Product Specific Information
This product is recommended as a detection antibody in Sandwich ELISA applications.
This clone can also be referred to as clone number 969D 4D11 2A9.
Target Information
Aggrecan also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1 is a protein that is encoded by the ACAN gene. The encoded protein is an integral part of the extracellular matrix in cartilaginous tissue and it withstands compression in cartilage. The human form of the protein is 2316 amino acids long (approximately 250 kDa) and can be expressed in multiple isoforms due to alternative splicing. Aggrecan exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate chains are attached to an extended protein core. The synthesis and degradation of aggrecan are being investigated for their roles in cartilage deterioration during joint injury, disease, and aging. It contains three interglobular domains (IGDs), G1, G2, and G3 that are involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis. Aggrecan fragments from articular cartilage are released into the synovial fluid at all stages of human osteoarthritis as a result of cleavage by aggrecanase and MMP activity. Antibodies BC-3 and BC-4 can be used to detect these neo epitopes of Aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Aggrecan core protein; Cartilage-specific proteoglycan core protein; Chondroitin sulfate proteoglycan 1; Chondroitin sulfate proteoglycan core protein 1; CSPCP; large aggregating proteoglycan; proteoglycan core protein; unnamed protein product
Gene Aliases: ACAN; AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK; SSOAOD
UniProt ID: (Human) P16112
Entrez Gene ID: (Human) 176
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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