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OriGene
ARNTL Monoclonal Antibody (OTI1C11), TrueMAB™
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Product Details
CF501174
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1C11
Immunogen
Full length human recombinant protein of human ARNTL produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARNT-like protein 1, brain and muscle; aryl hydrocarbon receptor nuclear translocator like; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic helix-loop-helix ARNT-like protein 1; basic helix-loop-helix family member e5; basic-helix-loop-helix-PAS orphan MOP3; Basic-helix-loop-helix-PAS protein MOP3; bHLH-PAS protein JAP3; bHLHe5; Brain and muscle ARNT-like 1; CG8727 PA; Class E basic helix-loop-helix protein 5; cycle; Member of PAS protein 3; member of PAS superfamily 3; MGC47515; mutant basic helix-loop-helix ARNT-like protein 1; PAS domain containing 3; PAS domain-containing protein 3; testis tissue sperm-binding protein Li 50e; unnamed protein product
Gene Aliases: ARNTL; ARNTL1; BHLHE5; BMAL1; BMAL1c; JAP3; MOP3; PASD3; TIC
UniProt ID: (Human) O00327
Entrez Gene ID: (Human) 406
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription cofactor activity
protein binding
aryl hydrocarbon receptor binding
sequence-specific DNA binding
protein dimerization activity
Hsp90 protein binding
E-box binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
circadian rhythm
negative regulation of TOR signaling
circadian regulation of gene expression
regulation of hair cycle
positive regulation of circadian rhythm
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
regulation of neurogenesis
regulation of insulin secretion
regulation of cell cycle
response to redox state
positive regulation of canonical Wnt signaling pathway
oxidative stress-induced premature senescence
energy homeostasis
negative regulation of cold-induced thermogenesis
positive regulation of protein acetylation
regulation of type B pancreatic cell development
negative regulation of glucocorticoid receptor signaling pathway
regulation of cellular senescence
positive regulation of skeletal muscle cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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