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OriGene
FOXP1 Monoclonal Antibody (OTI1G7), TrueMAB™
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Product Details
CF506701
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1G7
Immunogen
Full length human recombinant protein of human FOXP1 produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ23741; Fork head related protein like B; fork head-related protein like B; Forkhead box protein P1; Forkhead box protein P1 (FOXP1); FOXP1; Glutamine rich factor 1; glutamine-rich factor 1; Mac-1-regulated forkhead; MFH; MGC12942; MGC88572; MGC99551; unnamed protein product
Gene Aliases: 12CC4; FOXP1; hFKH1B; HSPC215; MFH; QRF1
UniProt ID: (Human) Q9H334
Entrez Gene ID: (Human) 27086
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
identical protein binding
sequence-specific DNA binding
metal ion binding
androgen receptor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
negative regulation of B cell apoptotic process
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
regulation of gene expression
positive regulation of endothelial cell migration
negative regulation of gene expression
striatum development
osteoclast differentiation
forebrain development
response to lipopolysaccharide
regulation of interleukin-1 beta production
regulation of interleukin-12 production
regulation of tumor necrosis factor production
positive regulation of interleukin-21 production
response to testosterone
osteoclast development
macrophage activation
monocyte activation
endothelial cell activation
regulation of monocyte differentiation
negative regulation of transcription, DNA-templated
animal organ development
positive regulation of smooth muscle cell proliferation
regulation of inflammatory response
positive regulation of B cell receptor signaling pathway
negative regulation of androgen receptor signaling pathway
negative regulation of cell growth involved in cardiac muscle cell development
T follicular helper cell differentiation
cellular response to tumor necrosis factor
regulation of defense response to bacterium
regulation of macrophage colony-stimulating factor production
positive regulation of hydrogen peroxide-mediated programmed cell death
regulation of endothelial tube morphogenesis
regulation of chemokine (C-X-C motif) ligand 2 production
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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