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Bethyl Laboratories
Phospho-SMC1 (Ser966) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-SMC1 (Ser966) Antibody (IHC-00016) in IHC (P)
Detection of mouse Phospho SMC1 (Ser 966) by immunohistochemistry. Samples: FFPE sections of mouse squamous cell carcinoma. Mock treatment (left panel) or lambda phosphatase-treatment (right panel). Antibody: Affinity purified rabbit anti-Phospho-SMC1 (Ser 966) (Product # IHC-00016) used at a dilution of 1:250. Detection: DAB.
Product Details
IHC-00016
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Phosphorylated synthetic peptide, which represented a portion of Human Structural Maintenance of Chromosomes 1 around serine 966.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Monkey, Northern white-cheeked gibbon, Small-eared galago, Crab-eating macaque and White-tufted-ear marmoset
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromo proteins are conserved in eukaryotes and lead to mitotic chromosome segregatior defects. This suggests a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. Mutations in the gene can lead to Cornelia de Lange syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chromosome segregation protein SmcB; DKFZp686L19178; epididymis secretory sperm binding protein; KIAA0178; MGC138332; mitosis-specific chromosome segregation protein like protein beta; mitosis-specific chromosome segregation protein SMC1 homolog; RP6-29D12.1; Sb1.8; segregation of mitotic chromosomes 1; segregation of mitotic chromosomes b; SM1A; SMC (segregation of mitotic chromosomes 1)-like 1; SMC protein 1A; SMC protein 1B; SMC-1-alpha; SMC-1-beta; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 2; SMC1alpha protein; structural maintenace of chromosomes 1B; Structural maintenance of chromosomes protein 1A; Structural maintenance of chromosomes protein 1B; unnamed protein product
Gene Aliases: 5830426I24Rik; CDLS2; DEE85; DXS423E; EIEE85; KIAA0178; mKIAA0178; SB1.8; SMC-1A; SMC-1B; SMC1; SMC1A; SMC1alpha; SMC1B; SMC1BETA; SMC1L1; SMC1L2; SMCB
UniProt ID: (Human) Q14683, (Human) Q8NDV3, (Mouse) Q9CU62, (Mouse) Q920F6
Entrez Gene ID: (Human) 8243, (Human) 27127, (Mouse) 24061, (Mouse) 140557
sister chromatid cohesion
chromosome organization
meiotic cell cycle
DNA repair
cellular response to DNA damage stimulus
cell cycle
mitotic sister chromatid cohesion
mitotic nuclear division
mitotic cell cycle checkpoint
meiotic nuclear division
stem cell population maintenance
negative regulation of DNA endoreduplication
signal transduction in response to DNA damage
cell division
mitotic sister chromatid segregation
response to radiation
establishment of mitotic sister chromatid cohesion
establishment of meiotic sister chromatid cohesion
somatic stem cell population maintenance
response to DNA damage checkpoint signaling
mitotic spindle assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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