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Bethyl Laboratories
EDD1 Polyclonal Antibody
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Product Details
IHC-00025
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 600 and 650 of human E3 Ubiquitin Protein Ligase, HECT domain containing 1.
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, X. tropicalis, Chicken, Turkey, Bovine, Dog, Horse, Pig, Panda, Orangutan, Monkey, Gorilla and Chimpanzee
Target Information
EDD (for E3 identified by Differential Display) is a progestin-regulated gene that was isolated from T-47D human breast cancer cells. Based on sequence homology, EDD appears to be a human homolog of the Drosophila hyperplastic discs (hyd) gene, a tumor suppressor gene that is required for control of imaginal disc growth. EDD contains a HECT domain in the carboxy terminus. HECT domain-containing proteins function as ubiquitin-protein ligases, or E3 enzymes. EDD has been shown to bind to ubiquitin, and like other HECT family proteins, may function as an E3 ubiquitin-protein ligase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CH D1S3362; E3 identified by differential display; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; ECGF1; EDG-1; EDG1; HECT E3; ubiquitin-protein ligase; HECT-type E3 ubiquitin transferase UBR5; hHYD; Hyperplastic discs protein homolog; Progestin-induced protein; S1P receptor 1; S1P receptor Edg-1; S1P1; S1PR1; unnamed protein product
Gene Aliases: DD5; EDD; EDD1; HYD; KIAA0896; UBR5
UniProt ID: (Human) O95071
Entrez Gene ID: (Human) 51366
protein polyubiquitination
DNA repair
cellular response to DNA damage stimulus
response to oxidative stress
proteasomal protein catabolic process
positive regulation of gene expression
protein ubiquitination
intracellular estrogen receptor signaling pathway
negative regulation of extent of heterochromatin assembly
protein K29-linked ubiquitination
positive regulation of protein import into nucleus
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of smoothened signaling pathway
retinoic acid receptor signaling pathway
progesterone receptor signaling pathway
vitamin D receptor signaling pathway
protein K48-linked ubiquitination
protein K11-linked ubiquitination
cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
positive regulation of canonical Wnt signaling pathway
cytoplasm protein quality control
DNA repair-dependent chromatin remodeling
protein branched polyubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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