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          • Primary Antibodies ›
          • MKL1 Antibodies

          Bethyl Laboratories

          MKL1 Polyclonal Antibody

          View all (35) MKL1 antibodies

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          Cite MKL1 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (1)
          MKL1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          MKL1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          MKL1 Antibody (IHC-00637) in IHC (P)

          Detection of human MKL1 by immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-MKL1 (Product # IHC-00637) used at a dilution of 1:250. Detection: DAB. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          MKL1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MKL1 Polyclonal Antibody

          Product Details

          IHC-00637

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (IHC)

          1:100-1:500
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:100-1:500
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Region between residue 700 and 750 of human megakaryoblastic leukemia (translocation) 1.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.25 mg/mL

          Amount

          25 µg

          Purification

          Antigen affinity chromatography

          Storage buffer

          TBS, pH 7.0 to 8.0, with 0.1% BSA

          Contains

          0.09% sodium azide

          Storage conditions

          4°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Product Specific Information

          The recommended shelf life for this product is 1 year from date of receipt.

          Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Gorilla, Chimpanzee, Northern white-cheeked gibbon and White-tufted-ear marmoset

          Target Information

          The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: alternative protein MKL1; basic, SAP and coiled-coil domain; megakaryoblastic leukemia (translocation) 1; Megakaryoblastic leukemia 1 protein; Megakaryocytic acute leukemia protein; mixed lineage leukemia; MKL/myocardin-like protein 1; MKL1; MRTF-A; Myocardin-related transcription factor A

          View more View less

          Gene Aliases: BSAC; KIAA1438; MAL; MKL; MKL1; MRTF-A; MRTFA

          View more View less

          UniProt ID: (Human) Q969V6

          View more View less

          Entrez Gene ID: (Human) 57591

          View more View less

          Function(s)
          transcription coactivator activity actin binding actin monomer binding protein binding leucine zipper domain binding
          Process(es)
          actin cytoskeleton organization wound healing, spreading of cells positive regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation positive regulation of pri-miRNA transcription from RNA polymerase II promoter
          It has to be done as per old AB suggested Products section.

          Disclaimer

          Close

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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