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Invitrogen
Caspase 6 Monoclonal Antibody (MCH2 14 1-190)
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FIGURE: 1 / 2
Caspase 6 Antibody (MA1-12558) in WB
Western blot was performed using Anti-Caspase 6 Monoclonal Antibody (MCH2 14 1-190) (Product # MA1-12558) and a 72 kDa band corresponding to Caspase 6 was observed across the cell lines tested. Whole cell extracts (30 µg lysate) of Jurkat (Lane 1) and OVAR-3 (Lane 2) were electrophoresed using Novex® NuPAGE® 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary anti... View More
Product Details
MA1-12558
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG
Class
Monoclonal
Type
Antibody
Clone
MCH2 14 1-190
Immunogen
Recombinant human capase-6 protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control for this product is MCF-7 cell lysate.
Target Information
Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Apoptotic protease Mch-2; CASP-6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6; mammalian Ced-3 homologue 2; mCASP-6
Gene Aliases: CASP6; caspase-6; CSP-6; MCH2
UniProt ID: (Human) P55212
Entrez Gene ID: (Human) 839
activation of innate immune response
proteolysis
apoptotic process
protein autoprocessing
epithelial cell differentiation
positive regulation of apoptotic process
regulation of programmed cell death
positive regulation of neuron apoptotic process
protein maturation
positive regulation of necroptotic process
pyroptosis
intrinsic apoptotic signaling pathway by p53 class mediator
cellular response to staurosporine
positive regulation of release of cytochrome c from mitochondria
hepatocyte apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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