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Invitrogen
ZPR1 Monoclonal Antibody (LG1)
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FIGURE: 1 / 4
ZPR1 Antibody (MA1-13003) in ICC/IF
Immunofluorescent analysis of ZPR1 in NIH-3T3 Cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with a ZPR1 monoclonal antibody (Product # MA1-13003) at a dilution of 1:20 overnight at 4 C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product # 35503). ZPR1 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Images were taken at 60X magnification.
Product Details
MA1-13003
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rabbit,
Yeast
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
LG1
Immunogen
murine ZPR1 protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-13003 detects ZPR1 in human and mouse samples.
MA1-13003 has been successfully been used in Immunofluorescence and Western Blot applications, where a band of ~50 kDa is detected.
The immunogen used to produce MA1-13003 was mouse ZPR1 protein.
Target Information
The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: unnamed protein product; Zinc finger protein 259; Zinc finger protein ZPR1
Gene Aliases: AI303781; GKAF; Zfp259; ZNF259; ZPR1
UniProt ID: (Human) O75312, (Mouse) Q62384
Entrez Gene ID: (Human) 8882, (Mouse) 22687
microtubule cytoskeleton organization
inner cell mass cell proliferation
trophectodermal cell proliferation
mRNA processing
multicellular organism development
RNA splicing
positive regulation of gene expression
spinal cord development
cell differentiation
Cajal body organization
regulation of myelination
positive regulation of RNA splicing
DNA endoreduplication
positive regulation of protein import into nucleus
positive regulation of growth
axon development
cellular response to epidermal growth factor stimulus
positive regulation of transcription involved in G1/S transition of mitotic cell cycle
apoptotic process involved in development
pre-mRNA catabolic process
negative regulation of motor neuron apoptotic process
DNA replication
protein folding
signal transduction
positive regulation of cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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