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Invitrogen

NOD2 Monoclonal Antibody (2D9)

3 Published Figures
4 References
View all (16) NOD2 antibodies

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Additional Information:
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NOD2 Monoclonal Antibody (2D9)

Product Details

MA1-16611

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100-1:2,000
View 2 publications 2 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:500
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-Dependent
-

Immunocytochemistry (ICC/IF)

1:50-1:500
View 1 publication 1 publication

Flow Cytometry (Flow)

Assay-Dependent
-

Immunoprecipitation (IP)

1:10-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2D9

Immunogen

Recombinant human NOD2 protein corresponding to residues 28-301.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_568643

Product Specific Information

The target sequence has 92% sequence homology with primate.

Target Information

NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: caspase recruitment domain family, member 15; caspase recruitment domain protein 15; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1; NLR family, CARD domain containing 2; NOD 2; NOD-2; NOD-like receptor C2; NOD2 protein; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2; Nucleotide-binding oligomerization domain-containing protein 2; unnamed protein product

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Gene Aliases: ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3; F830032C23Rik; IBD1; NLRC2; NOD2; NOD2B; PSORAS1; YAOS

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UniProt ID: (Human) Q9HC29

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Entrez Gene ID: (Human) 64127, (Mouse) 257632

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Function(s)
nucleotide binding actin binding protein binding ATP binding enzyme binding protein kinase binding Hsp70 protein binding muramyl dipeptide binding pattern recognition receptor activity peptidoglycan binding ubiquitin binding anion binding ADP binding macromolecular complex binding CARD domain binding Hsp90 protein binding carbohydrate derivative binding endodeoxyribonuclease activity, producing 5'-phosphomonoesters non-motor microtubule binding protein scaffold/adaptor protein
Process(es)
temperature homeostasis pattern recognition receptor signaling pathway adaptive immune response immune system process positive regulation of dendritic cell antigen processing and presentation positive regulation of cytokine production involved in immune response positive regulation of dendritic cell cytokine production positive regulation of type 2 immune response autophagy defense response I-kappaB kinase/NF-kappaB signaling response to nutrient positive regulation of cell proliferation detection of biotic stimulus detection of bacterium maintenance of gastrointestinal epithelium regulation of appetite response to muramyl dipeptide detection of muramyl dipeptide positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade intracellular signal transduction intestinal stem cell homeostasis p38MAPK cascade defense response to bacterium regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade innate immune response positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of gamma-delta T cell activation host-mediated regulation of intestinal microbiota composition positive regulation of epithelial cell proliferation regulation of inflammatory response positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 2 signaling pathway protein K63-linked ubiquitination cellular response to lipopolysaccharide cellular response to peptidoglycan cellular response to muramyl dipeptide protein linear polyubiquitination antibacterial innate immune response positive regulation of cytokine production involved in inflammatory response positive regulation of NIK/NF-kappaB signaling positive regulation of mitophagy positive regulation of protein K63-linked ubiquitination negative regulation of macrophage apoptotic process innate immune response in mucosa activation of immune response cytokine production involved in immune response cytokine secretion involved in immune response immunoglobulin production involved in immunoglobulin mediated immune response negative regulation of T cell mediated immunity negative regulation of inflammatory response to antigenic stimulus positive regulation of humoral immune response mediated by circulating immunoglobulin inflammatory response positive regulation of antibacterial peptide biosynthetic process positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria signal transduction positive regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity response to peptidoglycan response to lipopolysaccharide negative regulation of interferon-gamma production negative regulation of interleukin-12 production negative regulation of interleukin-18 production negative regulation of interleukin-2 production negative regulation of tumor necrosis factor production positive regulation of interleukin-12 production negative regulation of toll-like receptor 2 signaling pathway activation of MAPK activity involved in innate immune response response to exogenous dsRNA positive regulation of phosphatidylinositol 3-kinase activity negative regulation of growth of symbiont in host positive regulation of innate immune response positive regulation of interleukin-1 beta secretion positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis defense response to Gram-positive bacterium protein oligomerization positive regulation of oxidoreductase activity positive regulation of nitric-oxide synthase biosynthetic process positive regulation of prostaglandin-endoperoxide synthase activity macrophage inflammatory protein-1 alpha production regulation of neutrophil chemotaxis positive regulation of prostaglandin-E synthase activity
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