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Invitrogen
hnRNP M1-M4 Monoclonal Antibody (1D8)
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FIGURE: 1 / 2
hnRNP M1-M4 Antibody (MA1-16673) in IHC (P)
Immunohistochemistry analysis of hnRNP M1-M4 in formalin fixed paraffin-embedded (FFPE) human tonsil. Samples were incubated with hnRNP M1-M4 monoclonal antibody (Product # MA1-16673) using a dilution of 1:500. The assay involved 20 minutes of heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0) and endogenous peroxidase quenching with peroxide block. The sections were incubated w... View More
Product Details
MA1-16673
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1D8
Immunogen
M19 fusion protein containing full-length human protein.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: antigen standard for HNRNPM (transient overexpression lysate).
Target Information
Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3'-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CEA receptor; Heterogeneous nuclear ribonucleoprotein M; heterogenous nuclear ribonucleoprotein M4; hnRNA-binding protein M4; hnRNP M; HNRNP3; HNRNPM3; M4 protein; N-acetylglucosamine receptor 1; ORF
Gene Aliases: 2610023M21Rik; AA409009; CEAR; hnRNP M; HNRNPM; HNRNPM4; HNRPM; HNRPM4; HTGR1; mKIAA4193; NAGR1
UniProt ID: (Human) P52272, (Rat) Q62826, (Mouse) Q9D0E1
Entrez Gene ID: (Bovine) 515290, (Pig) 100514153, (Human) 4670, (Rabbit) 100356502, (Rat) 116655, (Mouse) 76936
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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