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Invitrogen
COMP Monoclonal Antibody (MA37C94 (HC484D1))
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FIGURE: 1 / 2
COMP Antibody (MA1-20221) in IHC
International journal of molecular sciences 2021 -
Figure 1 Retention of human mutant-COMP in ER of MT-COMP articular chondrocytes at 4 weeks, with CHOP expression at 12 weeks. All mice were administered DOX from birth to collection at 2, 4, 8, 12, 16, and 20 weeks. Dotted line marks the edge of articular cartilage. Control and MT-COMP tibial articular cartilages were immunostained using human COMP-specific antibodies (red) and protein disulfide isomerase (... View More
Product Details
MA1-20221
Applications
Tested Dilution
Publications
Product Specifications
Published species
Mouse
Host/Isotype
Rat
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
MA37C94 (HC484D1)
Immunogen
Human cartilage derived COMP
Conjugate
Form
Liquid
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
MA1-20221 detects COMP in human samples.
MA1-20221 has been successfully used in ELISA, immunoprecipitation, immunohistochemistry (frozen and paraffin) and Western blot applications. Predicted molecular weight 82.8 kDa.
The MA1-20221 immunogen is human cartilage derived COMP.
Target Information
COMP is a noncollagenous extracellular matrix protein. It consists of five identical glycoprotein subunits, each with EGF like and calcium binding (thrombospondin like) domains. Oligomerization results from formation of a five stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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