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Invitrogen
CXCR1 Monoclonal Antibody (501)
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FIGURE: 1 / 4
CXCR1 Antibody (MA1-206) in ICC/IF
Immunofluorescent analysis of CXCR1/IL8RA (green) in MCF7 cells. Cells were blocked with blocking buffer (Product # 37525) for 30 min at room temparture and then stained with CXCR1/IL8RA mouse monoclonal antibody (Product # MA1-206) at a dilution of 1:100 for 1 hour at room temperature. After washing with PBS for 3 times, the cells were then stained with Alexa Fluor 488 goat anti-mouse secondary antibody (Product # A28175) for 1 hour at room temperature. The cells were fixed with 4% paraformaldehyde for 30 minutes at room temperature. Nucl... View More
Product Details
MA1-206
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
501
Immunogen
Synthetic peptide corresponding to the N-terminal residues 5-19 of human CXCR1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 1mg/mL BSA, 30% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-206 detects CXCR1/IL8RA from human samples.
MA1-206 has been successfully tested in western blot, immunofluorescence and flow cytometry applications. In western blot, MA1-206 detects CXCR1/IL8RA (human) at approximate molecular weight of 30 kDa.
Target Information
CXCR1 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 1; CC motif chemokine; CCmotif chemokine; CD181; CDw128a; chemokine (C-X-C motif) receptor 1; CXC; CXC motif chemokine; CXC-R1; CXCR-1; High affinity interleukin-8 receptor A; IL-8 Receptor alpha; IL-8 Receptor IL-RA; IL-8 receptor type 1; IL-8R A; IL-RA; IL8RA; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A; unnamed protein product
Gene Aliases: C-C; C-C-CKR-1; CD128; CD181; CDw128a; CKR-1; CMKAR1; CXCR1; IL8R1; IL8RA; IL8RBA
UniProt ID: (Human) P25024
Entrez Gene ID: (Human) 3577
dendritic cell chemotaxis
chemotaxis
immune response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
calcium-mediated signaling
neutrophil chemotaxis
receptor internalization
interleukin-8-mediated signaling pathway
chemokine-mediated signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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