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Invitrogen
LMO2 Monoclonal Antibody (1A9-3B11)
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FIGURE: 1 / 4
LMO2 Antibody (MA1-46422) in IHC (P)
Immunohistochemistry analysis of LMO2 in formalin fixed paraffin-embedded (FFPE) human tonsil. Samples were incubated with LMO2 monoclonal antibody (Product # MA1-46422) using a dilution of 1:500. The assay involved 20 minutes of heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0) and endogenous peroxidase quenching with peroxide block. The sections were incubated with primary an... View More
Product Details
MA1-46422
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1A9-3B11
Immunogen
Recombinant human LMO2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: OCIL-Y19, Raji or Ramos whole cell lysates.
Negative control is Hela whole cell lysates.
Target Information
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cysteine-rich protein TTG-2; LIM domain only protein 2; LIM only 2; LMO-2; Rhombotin-2; rhombotin-like 1; T-cell translocation gene 2; T-cell translocation protein 2; TTG-2a/RBTN-2a; TTG2/RBTN2
Gene Aliases: LMO-2; LMO2; Rbtn-2; RBTN2; RBTNL1; Rhom-2; RHOM2; TTG2
UniProt ID: (Human) P25791, (Mouse) P25801
Entrez Gene ID: (Human) 4005, (Mouse) 16909
transcription cofactor binding
transcription coactivator activity
protein binding
identical protein binding
bHLH transcription factor binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
DNA-binding transcription factor binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
zinc ion binding
cofactor binding
E-box binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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