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Invitrogen

RARB Monoclonal Antibody (336)

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RARB Monoclonal Antibody (336)

Product Details

MA1-4670

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Rat

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

336

Immunogen

Synthetic peptide corresponding to the N-terminal region of human RARB conjugated to KLH
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

50 µg

Purification

Protein G

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_560887

Product Specific Information

This antibody is predicted to react with canine, guinea pig, mouse and non-human primate based on 100% sequence homology.

This antibody is specific for the ~48 kDa RXR-b protein.

Target Information

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 2; nuclear receptor; RAR beta; open reading frame 1; putative; RAR beta; RAR beta 1'; RAR-b; RAR-beta; RAR-Beta2; RAR-Beta4; RAR-epsilon; RARB; RARbeta isoform 5; retinoic acid; retinoic acid receptor; Retinoic acid receptor beta; retinoic acid receptor, beta polypeptide; unnamed protein product

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Gene Aliases: HAP; MCOPS12; NR1B2; RARB; RARbeta; RARbeta1; RRB2

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UniProt ID: (Human) P10826

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Entrez Gene ID: (Human) 5915, (Rat) 24706

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding sequence-specific DNA binding macromolecular complex binding metal ion binding retinoid X receptor binding heterocyclic compound binding sequence-specific double-stranded DNA binding RNA polymerase II regulatory region sequence-specific DNA binding steroid hormone receptor activity retinoic acid receptor activity drug binding protein complex binding C4 zinc finger nuclear receptor
Process(es)
negative regulation of transcription from RNA polymerase II promoter ureteric bud development glandular epithelial cell development outflow tract septum morphogenesis growth plate cartilage development regulation of transcription, DNA-templated apoptotic process signal transduction cell proliferation programmed cell death striatum development neurogenesis cell differentiation regulation of myelination negative regulation of chondrocyte differentiation embryonic hindlimb morphogenesis multicellular organism growth positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death positive regulation of transcription from RNA polymerase II promoter embryonic eye morphogenesis retinoic acid receptor signaling pathway embryonic digestive tract development ventricular cardiac muscle cell differentiation bone development negative regulation of cartilage development neural precursor cell proliferation stem cell proliferation negative regulation of stem cell proliferation retinal pigment epithelium development transcription, DNA-templated positive regulation of cell proliferation negative regulation of cell proliferation steroid hormone mediated signaling pathway positive regulation of neuron differentiation retina development in camera-type eye
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