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Invitrogen
Complement C4d Monoclonal Antibody (10-11)
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Product Details
MA1-83082
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
10-11
Immunogen
Native protein, from human plasma.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Chromatography
Storage buffer
BBS, pH 8.4
Contains
<0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody does not react with bovine, cat, dog, guinea pig, mouse, rabbit, rat or sheep.
It has been reported that this antibody works very well on acetone-fixed, frozen renal biopsies. Strong staining is observed in the glomeruli and in some cases the peritubular capillaries. Clone 10-11 has given variable results on formalin-fixed, paraffin-embedded sections. It has been observed that pre-treatment with 88% formic acid for 20 minutes at room temperature is beneficial.
Mouse anti Human C4d antibody, clone 10-11 recognizes the secreted protein complement component 4d (C4d).
Target Information
C4 is a component of the classical complement pathway and is split by activated C1s to C4a and C4b. Together C2a and C4b forms the classical C3 convertase. The molecular mass of C4 is 204 kDa and it consists of 3 subunits: a (97 kDa), b (75 kDa) and g (33 kDa).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acidic C4; Acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; c4 complement; c4 propeptide; C4A anaphylatoxin; C4D; Chido form of C4; Complement C4-A; Complement C4-B; complement C4A (Rodgers blood group); complement C4B (Chido blood group); complement C4B1a; complement component 4A (Rodgers blood group); complement component 4B (Chido blood group); complement component 4B (Chido blood group), copy 2; DADB-112B14.11; FLJ60561; MGC164979; MHC class III region complement; Rodgers form of C4; unnamed protein product; ZA
Gene Aliases: C4; C4A; C4A2; C4A3; C4A4; C4A6; C4AD; C4B; C4B1; C4B12; C4B2; C4B3; C4B5; C4B_2; C4BD; C4F; C4S; CH; CO4; CPAMD2; CPAMD3; RG
UniProt ID: (Human) P0C0L4, (Human) P0C0L5
Entrez Gene ID: (Human) 720, (Human) 721, (Human) 100293534
immune system process
inflammatory response
complement activation
complement activation, classical pathway
opsonization
detection of molecule of bacterial origin
innate immune response
complement activation, GZMK pathway
positive regulation of apoptotic cell clearance
complement activation, lectin pathway
activation of membrane attack complex
killing of cells of other organism
protein maturation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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