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Invitrogen

Caveolin 1 Monoclonal Antibody (7C8)

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10 Published Figures
11 References
View all (46) Caveolin 1 antibodies

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Caveolin 1 Monoclonal Antibody (7C8)

Product Details

MA3-600

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:2,000
View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20
-

Immunocytochemistry (ICC/IF)

1:125
View 4 publications 4 publications

Flow Cytometry (Flow)

Assay-dependent
-

Immunoprecipitation (IP)

1-3 µL
-
Product Specifications

Species Reactivity

Hamster, Human, Rat

Published species

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

7C8

Immunogen

Intercellular membrane protein-containing vesicles (containing GLUT4) from rat.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_779568

Product Specific Information

MA3-600 detects caveolin from human, rat and hamster samples.

MA3-600 has been successfully used in Western blot, immunofluorescence, and immunoprecipitation procedures. By Western blot, this antibody detects a 19-21 kDa band from transfected HEK293 (B8) cells, with a non-specific band appearing at 65-70 kDa.

The MA3-600 immunogen is intercellular membrane protein-containing vesicles obtained from rat.

Target Information

Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: caveolae; caveolin 1, caveolae protein, 22kDa; caveolin caveolae protein 22 kDa; Caveolin-1; cell growth-inhibiting protein 32; GIG32; HGNC:1527; OTTHUMP00000196475; unnamed protein product

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Gene Aliases: BSCL3; CAV; CAV1; Caveolin-1; CGL3; LCCNS; MSTP085; PPH3; VIP21

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UniProt ID: (Human) Q03135

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Entrez Gene ID: (Human) 857, (Rat) 25404, (Chinese hamster) 100753021

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Function(s)
receptor binding patched binding protein binding oxysterol binding cholesterol binding peptidase activator activity enzyme binding protein kinase binding protein tyrosine kinase inhibitor activity protein binding, bridging small GTPase binding nitric-oxide synthase inhibitor activity identical protein binding ion channel binding macromolecular complex binding protein heterodimerization activity nitric-oxide synthase binding ATPase binding binding, bridging inward rectifier potassium channel inhibitor activity protein sequestering activity SNARE binding RNA polymerase I transcription factor binding structural molecule activity kinase binding syntaxin binding protein complex scaffold MDM2/MDM4 family protein binding scaffold/adaptor protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade angiogenesis vasculogenesis response to hypoxia endothelial cell proliferation negative regulation of endothelial cell proliferation negative regulation of cytokine-mediated signaling pathway regulation of the force of heart contraction glandular epithelial cell differentiation response to ischemia regulation of the force of heart contraction by chemical signal triglyceride metabolic process nitric oxide biosynthetic process calcium ion transport cellular calcium ion homeostasis regulation of smooth muscle contraction skeletal muscle tissue development lactation protein localization cell proliferation negative regulation of cell proliferation cellular response to starvation response to bacterium negative regulation of signal transduction positive regulation of calcium ion transport into cytosol posttranscriptional regulation of gene expression positive regulation of gene expression positive regulation of cholesterol efflux protein transport vesicle organization receptor-mediated endocytosis of virus by host cell regulation of fatty acid metabolic process cytokine-mediated signaling pathway lipid storage cell differentiation regulation of blood coagulation cholesterol transport positive regulation of cell migration negative regulation of BMP signaling pathway negative regulation of epithelial cell differentiation mammary gland development T cell costimulation negative regulation of protein ubiquitination positive regulation of protein ubiquitination receptor internalization maintenance of protein location in cell response to progesterone nitric oxide homeostasis toll-like receptor 4 signaling pathway regulation of toll-like receptor 4 signaling pathway insulin receptor internalization angiotensin-activated signaling pathway vasoconstriction cholesterol homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAPK cascade response to estrogen protein localization to plasma membrane raft negative regulation of nitric oxide biosynthetic process positive regulation of vasoconstriction nitric oxide metabolic process negative regulation of JAK-STAT cascade muscle cell cellular homeostasis fibroblast proliferation negative regulation of fibroblast proliferation negative regulation of pinocytosis regulation of cytosolic calcium ion concentration response to calcium ion establishment of localization in cell membrane depolarization calcium ion homeostasis mammary gland involution canonical Wnt signaling pathway negative regulation of necroptotic process caveola assembly cellular response to misfolded protein cellular response to peptide hormone stimulus cellular response to hyperoxia cellular response to transforming growth factor beta stimulus basement membrane organization caveolin-mediated endocytosis regulation of heart rate by cardiac conduction negative regulation of canonical Wnt signaling pathway apoptotic signaling pathway regulation of membrane repolarization during action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of ventricular cardiac muscle cell action potential positive regulation of cold-induced thermogenesis regulation of ruffle assembly negative regulation of potassium ion transmembrane transport regulation of cell communication by electrical coupling involved in cardiac conduction protein localization to basolateral plasma membrane positive regulation of gap junction assembly positive regulation of ERAD pathway regulation of entry of bacterium into host cell negative regulation of anoikis positive regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway inactivation of MAPK activity positive regulation of endothelial cell proliferation response to nutrient response to mechanical stimulus positive regulation of signal transduction response to gamma radiation negative regulation of muscle cell apoptotic process positive regulation of peptidase activity organ regeneration positive regulation of microtubule polymerization negative regulation of protein binding negative regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation cholesterol efflux wound healing response to drug negative regulation of tyrosine phosphorylation of Stat5 protein positive regulation of catalytic activity negative regulation of MAP kinase activity negative regulation of neuron differentiation positive regulation of endocytosis microtubule polymerization negative regulation of smooth muscle cell proliferation negative regulation of nitric-oxide synthase activity protein oligomerization protein homooligomerization response to glucocorticoid regulation of peptidase activity negative regulation of protein tyrosine kinase activity negative regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus angiotensin-activated signaling pathway involved in heart process positive regulation of canonical Wnt signaling pathway cellular senescence negative regulation of peptidyl-tyrosine autophosphorylation regulation of inward rectifier potassium channel activity receptor internalization involved in canonical Wnt signaling pathway negative regulation of cation channel activity
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