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Invitrogen
alpha Internexin Monoclonal Antibody (1D2)
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FIGURE: 1 / 3
alpha Internexin Antibody (MA3-16752) in ICC/IF
Immunocytochemistry analysis of alpha Internexin in mixed cultures of rat CNS cells. Samples were incubated with alpha Internexin monoclonal antibody (Product # MA3-16752). Primary antibody (red) and chicken antibody to Microtubule associated protein 2 (MAP2- green). The a-internexin is localized primarily in neuronal axons in these cultures, while the perikarya and dendrites of neurons stain strongly for M... View More
Product Details
MA3-16752
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Cat,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1D2
Immunogen
Purified recombinant rat alpha-internexin expressed in and purified from E. coli.
Conjugate
Form
Liquid
Concentration
1
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.035% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
alpha-Internexin is a Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain a-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons a-internexin is the only neurofilament subunit expressed. Antibodies to internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of a-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 66 kDa neurofilament protein; Alpha-internexin; Alpha-Inx; FLJ18662; FLJ57501; internexin, alpha; MGC12702; Neuro; Neurofilament 5; neurofilament 5 (66kD); Neurofilament 66; neurofilament-66; neurofilament-66, tax-binding protein; NF-66; unnamed protein product
Gene Aliases: AV028420; INA; Inexa; Intlaa; NEF5; NF-66; NF66; TXBP-1
UniProt ID: (Human) Q16352, (Mouse) P46660
Entrez Gene ID: (Human) 9118, (Mouse) 226180, (Rat) 24503
multicellular organism development
nervous system development
cell differentiation
intermediate filament cytoskeleton organization
neurofilament cytoskeleton organization
substantia nigra development
tissue regeneration
intermediate filament organization
postsynaptic modulation of chemical synaptic transmission
postsynaptic intermediate filament cytoskeleton organization
cellular response to leukemia inhibitory factor
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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