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Invitrogen
Triadin Monoclonal Antibody (GE 4.90)
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Product Details
MA3-927
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rabbit,
Rat
Published species
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG
Class
Monoclonal
Type
Antibody
Clone
GE 4.90
Immunogen
Purified rabbit fast skeletal muscle triadin.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA3-927 detects triadin from mouse, rabbit and rat tissues.
MA3-927 has been successfully used in Western blot, immunohistochemistry, immunoprecipitation and ELISA procedures. By Western blot, this antibody detects a 95 kDa protein representing triadin from rabbit skeletal muscle extracts. Immunohistochemical staining of triadin in rat skeletal muscle with MA3-927 results in striated staining consistent with sarcoplasmic reticulum localization.
The MA3-927 antigen is purified rabbit fast skeletal muscle triadin.
Target Information
The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR's) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR's), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (MW 95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPR's and RyR's. Though its exact role in this signaling process is unclear, triadin has been shown to co-localize with both DHPR and RYR at the junctional face of the terminal cisternae.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cardiac triadin; junctional sarcoplasmic reticulum glycoprotein; Triadin; triadin 1; triadin 32 kDa (TRISK 32); triadin 49 kDa (TRISK 49); triadin 95
Gene Aliases: 2310045H21Rik; EG432451; TDN; TRDN
UniProt ID: (Rabbit) Q28820, (Rat) Q9QX75, (Mouse) E9Q9K5
Entrez Gene ID: (Rabbit) 100009519, (Rat) 59299, (Mouse) 76757
cellular calcium ion homeostasis
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to organic cyclic compound
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
myotube differentiation
cytoplasmic microtubule organization
negative regulation of release of sequestered calcium ion into cytosol
positive regulation of release of sequestered calcium ion into cytosol
heart contraction
endoplasmic reticulum membrane organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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