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Invitrogen

ErbB3 Monoclonal Antibody (2F12)

Advanced Verification
2 Published Figures
27 References
View all (99) Her-3 (ErbB3) antibodies

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Product Details

MA5-12675

Applications
Tested Dilution
Publications

Western Blot (WB)

4 µg/mL
View 13 publications 13 publications

Immunohistochemistry (IHC)

-
View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

-
View 6 publications 6 publications

Immunoprecipitation (IP)

-
View 5 publications 5 publications

Neutralization (Neu)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Bovine, Human, Mouse, Rat

Published species

Human, Mouse, Non-human primate, Rat

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

2F12

Immunogen

Recombinant rat c-erbB-3/HER-3 oncoprotein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11001597

Product Specific Information

MA5-12675 targets HER-3 in WB applications and shows reactivity with Bovine, Human, mouse, and Rat samples.

The MA5-12675 immunogen is recombinant rat c-erbB-3/HER-3 oncoprotein.

Target Information

ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. ErbB3 is over-expressed in a variety of tumors in the prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents. The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6. 2kb mRNA which is translated into a 160/180 kDa glycoprotein. The ErbB3 gene encodes a transmembrane receptor tyrosine kinase due to alternative splicing and forms heterodimers with other EGF receptor family members that have kinase activity. Heterodimerization leads to the activation of pathways that lead to cell proliferation or differentiation. Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized. One ErbB3 isoform lacks the intermembrane region, is secreted outside the cell, and acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: avian erythroblastosis oncogene B 3; avian erythroblastosis oncogene B 3 receptor; c-erbB-3; c-erbB3; C-errB-3; epidermal growth factor receptor precursor; Glial growth factor receptor; HER3 protein precursor; human epidermal growth factor receptor 3; MDA BF 1; MGC88033; p180 ErbB3; p45 sErbB3; p85 sErbB3; Proto-oncogene-like protein c-ErbB-3; receptor tyrosine kinase; Receptor tyrosine-protein kinase erbB-3; Tyrosine kinase-type cell surface receptor HER3; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

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Gene Aliases: c-erbB-3; c-erbB3; C76256; ErbB-3; ERBB3; erbB3-S; Erbb3r; FERLK; HER3; LCCS2; MDA-BF-1; nuc-ErbB3; p180-ErbB3; p45-sErbB3; p85-sErbB3; VSCN1

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UniProt ID: (Human) P21860, (Mouse) Q61526, (Rat) Q62799

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Entrez Gene ID: (Human) 2065, (Bovine) 785655, (Mouse) 13867, (Rat) 29496

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane signaling receptor activity protein binding ATP binding kinase activity transferase activity growth factor binding protein tyrosine kinase activator activity ubiquitin protein ligase binding signaling receptor activity neuregulin receptor activity neuregulin binding identical protein binding ErbB-3 class receptor binding protein heterodimerization activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
Process(es)
endocardial cushion development negative regulation of cell adhesion signal transduction transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway peripheral nervous system development heart development negative regulation of signal transduction positive regulation of gene expression Schwann cell differentiation Schwann cell development cranial nerve development neuron differentiation ERBB2-ERBB3 signaling pathway wound healing regulation of cell proliferation myelination negative regulation of apoptotic process positive regulation of MAPK cascade protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of epithelial cell proliferation negative regulation of secretion neuron apoptotic process positive regulation of protein kinase B signaling positive regulation of cardiac muscle tissue development positive regulation of calcineurin-NFAT signaling cascade motor neuron apoptotic process extrinsic apoptotic signaling pathway in absence of ligand negative regulation of motor neuron apoptotic process protein phosphorylation phosphatidylinositol 3-kinase signaling phosphorylation positive regulation of glucose import positive regulation of protein tyrosine kinase activity axonogenesis skeletal muscle tissue development circadian rhythm response to wounding peptidyl-tyrosine phosphorylation signal transduction by protein phosphorylation cellular response to insulin stimulus odontogenesis response to drug tongue development mammary gland involution
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