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Invitrogen
Synaptophysin Monoclonal Antibody (SP11)
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FIGURE: 1 / 22
Synaptophysin Antibody (MA5-14532) in ICC/IF
Immunofluorescence analysis of Synaptophysin was done on 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Synaptophysin (SP11) Rabbit Monoclonal Antibody (Product # MA5-14532) at 1:250 dilution in 0.1% BSA and incubated ... View More
Product Details
MA5-14532
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Cynomolgus monkey,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
SP11
Immunogen
A synthetic peptide of human synaptophysin (aa 250-313).
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
tissue culture supernatant/TBS, pH 7.5, with 1% BSA
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-14532 targets Synaptophysin in IHC (P) and WB applications and shows reactivity with Human samples.
The MA5-14532 immunogen is a synthetic peptide of human synaptophysin.
Target Information
Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BM89 antigen; Major synaptic vesicle protein p38; Synaptophysin; Syp I; unnamed protein product
Gene Aliases: A230093K24Rik; AI848995; MRX96; MRXSYP; p38; Syn; SYP; Syp1; XLID96
UniProt ID: (Human) P08247, (Rat) P07825, (Mouse) Q62277
Entrez Gene ID: (Human) 6855, (Rat) 24804, (Mouse) 20977
endocytosis
regulation of synaptic vesicle priming
synaptic vesicle maturation
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
regulation of short-term neuronal synaptic plasticity
synaptic vesicle membrane organization
modulation of synaptic transmission
regulation of opioid receptor signaling pathway
cellular response to organic substance
transport
chemical synaptic transmission
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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