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Invitrogen

Bcl-10 Monoclonal Antibody (4F8)

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Product Details

MA5-14756

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

1:200-1:1,000
-

Flow Cytometry (Flow)

1:200-1:400
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4F8

Immunogen

Purified recombinant fragment of human BCL-10 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10977153

Product Specific Information

MA5-14756 targets BCL-10 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human and mouse samples.

The MA5-14756 immunogen is purified recombinant fragment of human BCL-10 expressed in E. Coli.

MA5-14756 detects BCL-10 which has a predicted molecular weight of approximately 26kDa.

Target Information

BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B cell CLL/lymphoma 10; B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; c-E10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; CARMEN; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; hCLAP; Mamm; Mammalian CARD-containing adapter molecule E10; mCIPER; mCLAP; mE10; OTTHUMP00000011647; OTTHUMP00000036080; protein binding; signal transducer activity; RP11-234D19.2; unnamed protein product

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Gene Aliases: AI132454; BCL-10; BCL10; c-E10; C81403; CARMEN; cE10; CIPER; CLAP; IMD37; ME10

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UniProt ID: (Human) O95999, (Mouse) Q9Z0H7

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Entrez Gene ID: (Human) 8915, (Mouse) 12042

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Function(s)
protease binding transcription coactivator activity protein binding kinase activator activity protein binding, bridging ubiquitin protein ligase binding signaling adaptor activity identical protein binding protein kinase B binding macromolecular complex binding CARD domain binding NF-kappaB binding general transcription initiation factor binding protein C-terminus binding transcription factor binding cysteine-type endopeptidase activator activity involved in apoptotic process enzyme binding kinase binding protein kinase binding protein homodimerization activity ubiquitin binding protein self-association protein heterodimerization activity
Process(es)
B cell apoptotic process positive regulation of cytokine production neural tube closure toll-like receptor signaling pathway adaptive immune response immune system process negative regulation of mature B cell apoptotic process apoptotic process cellular defense response response to fungus programmed cell death immunoglobulin mediated immune response positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway response to food response to lipopolysaccharide positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of lymphotoxin A production positive regulation of mast cell cytokine production NIK/NF-kappaB signaling positive regulation of phosphorylation regulation of apoptotic process positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of transcription, DNA-templated T cell receptor signaling pathway regulation of T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity protein homooligomerization antifungal innate immune response T cell apoptotic process cellular response to lipopolysaccharide cellular response to mechanical stimulus apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic process I-kappaB kinase/NF-kappaB signaling activation of JUN kinase activity cell death positive regulation of cysteine-type endopeptidase activity involved in apoptotic process fibroblast apoptotic process positive regulation of interleukin-8 biosynthetic process mast cell activation protein oligomerization protein heterooligomerization thymocyte apoptotic process positive regulation of execution phase of apoptosis
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