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Invitrogen
FGFR3 Monoclonal Antibody (T.994.9)
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Product Details
MA5-14843
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
T.994.9
Immunogen
GST-FGFR-3 cytoplasmic domain fusion protein
Conjugate
Form
Liquid
Concentration
27 µg/mL
Amount
2.7 µg
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other related family members.
Target Information
FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD333; FGF Receptor; FGFR; FGFR-3; FGFR3deltaTM; Fibroblast growth factor receptor 3; fibroblast growth factor receptor 3-S; growth factor receptor; hydroxyaryl-protein kinase; tyrosine kinase; tyrosine kinase JTK4; tyrosine kynase receptor
Gene Aliases: ACH; CD333; CEK2; FGFR3; HSFGFR3EX; JTK4
UniProt ID: (Human) P22607
Entrez Gene ID: (Human) 2261
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
fibroblast growth factor-activated receptor activity
protein binding
ATP binding
kinase activity
transferase activity
fibroblast growth factor binding
identical protein binding
MAPK cascade
skeletal system development
ossification
endochondral ossification
chondrocyte differentiation
endochondral bone growth
apoptotic process
JAK-STAT cascade
cell-cell signaling
cell proliferation
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
positive regulation of phospholipase activity
bone mineralization
chondrocyte proliferation
positive regulation of tyrosine phosphorylation of STAT protein
positive regulation of MAPK cascade
negative regulation of developmental growth
cartilage development
positive regulation of protein kinase B signaling
bone morphogenesis
positive regulation of ERK1 and ERK2 cascade
bone maturation
fibroblast growth factor receptor apoptotic signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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