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Invitrogen

Phospho-p70 S6 Kinase (Thr389) Monoclonal Antibody (R.566.2)

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Phospho-p70 S6 Kinase (Thr389) Monoclonal Antibody (R.566.2)

Product Details

MA5-15202

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Fruit fly, Human, Mouse, Non-human primate, Rat

Published species

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

R.566.2

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding pThr389 of human p70 S6 kinase
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

719 µg/mL

Amount

71.9 µg

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10978757

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

RPS6KB1 (p70S6K) is a serine/threonine kinase with 2 non-identical kinase catalytic domains which phosphorylates several residues of the S6 ribosomal protein. p70 S6 kinase is predominantly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 70 kDa ribosomal protein S6 kinase 1; CG10539-PA; CG10539-PB; Dp70s6k; dS6 kinase; EC 2.7.11.1; kinase p70S6K; KS6B1; p70 p70-S6K; p70 ribosomal S6 kinase; p70 ribosomal S6 kinase alpha; p70 S6 kinase; p70 S6 kinase 1; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA; p70(S6K)-alpha; p70-S6K 1; p70S6 kinase; P70S6K; p70S6K kinase; p70S6K-alpha; P70S6K1; p80-S6K 1; p85 p85S6K; protein kinase-like 64F; Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kD, polypeptide 1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; ribosomal S6 protein kinase; RPS6-p70-protein kinase; S6 kinase; S6-kinase; S6K; S6K kinase; S6K-beta-1; S6k-PA; S6k-PB; S6K1; S6kinase; serine/threonine kinase 14 alpha; Serine/threonine-protein kinase 14A; unnamed protein product

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Gene Aliases: 10539; 2610318I15Rik; 4732464A07Rik; 7-10; 7084; 70kDa; AA959758; AI256796; AI314060; CG10539; d-S6K; Dmel\CG10539; Dmel_CG10539; Dp70[s6k]; Dp70S6k; dps6k; DS6K; dS6K1; fs(3)07084; l(3)07084; p-S6K; p70 S6K; p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; p70/85s6k; p70/S6K; p70[S6 kinase]; p70[S6K]; p70[S6kinase]; p70S6K; Pk64F; Pk?6; PS6K; RPS6KB1; S6 K; S6K; S6K-beta-1; S6K1; s6k11; S6k|S6K; STK14A

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UniProt ID: (Human) P23443, (Mouse) Q8BSK8, (Rat) P67999

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Entrez Gene ID: (Human) 6198, (Mouse) 72508, (Rat) 83840, (Fruit fly) 38654

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding kinase activity transferase activity protein serine kinase activity ribosomal protein S6 kinase activity transferase activity, transferring phosphorus-containing groups PDZ domain binding peptide binding protein phosphatase 2A binding protein modifying enzyme
Process(es)
autophagosome assembly G1/S transition of mitotic cell cycle behavioral fear response cytoplasmic translation regulation of translation ubiquitin-dependent protein catabolic process apoptotic process signal transduction germ cell development insulin receptor signaling pathway negative regulation of autophagy positive regulation of autophagy peptidyl-serine phosphorylation SCF-dependent proteasomal ubiquitin-dependent protein catabolic process response to nutrient levels cellular response to nutrient levels cellular response to nutrient TOR signaling cellular response to insulin stimulus TORC1 signaling TORC2 signaling negative regulation of apoptotic process protein kinase B signaling long-chain fatty acid import positive regulation of translation positive regulation of mitotic cell cycle positive regulation of translational initiation negative regulation of insulin receptor signaling pathway phosphatidylinositol-mediated signaling modulation of synaptic transmission positive regulation of protein kinase B signaling cellular response to interferon-gamma cellular response to growth factor stimulus cellular response to dexamethasone stimulus negative regulation of TORC2 signaling negative regulation of TORC1 signaling positive regulation of TORC1 signaling negative regulation of extrinsic apoptotic signaling pathway protein phosphorylation cell cycle positive regulation of smooth muscle cell migration phosphorylation response to insulin response to tumor necrosis factor regulation of glucose import positive regulation of skeletal muscle tissue growth positive regulation of smooth muscle cell proliferation cellular response to organic cyclic compound skeletal muscle contraction aging response to nutrient long-term memory response to heat response to wounding response to mechanical stimulus response to toxic substance response to glucose response to organic substance response to organonitrogen compound response to organic cyclic compound skeletal muscle atrophy response to electrical stimulus involved in regulation of muscle adaptation cell migration response to lipopolysaccharide cellular response to hormone stimulus response to testosterone response to glucagon response to drug response to amino acid response to leucine response to peptide hormone response to ethanol response to glucocorticoid response to oxidative stress determination of adult lifespan positive regulation of cell growth larval feeding behavior multicellular organism growth intracellular signal transduction female germ-line stem cell population maintenance positive regulation of cell size vascular endothelial growth factor receptor signaling pathway dendrite morphogenesis synaptic growth at neuromuscular junction lipid homeostasis cellular response to amino acid stimulus positive regulation of axon guidance regulation of terminal button organization regulation of response to drug
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