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Invitrogen
CK1 alpha Monoclonal Antibody (3C10F7, 3C10G5, PMC01, 4D12B3,3C10F7C11)
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Product Details
MA5-15300
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3C10F7, 3C10G5, PMC01, 4D12B3,3C10F7C11
Immunogen
Purified recombinant fragment of CK1 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15300 targets CK1 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.
The MA5-15300 immunogen is purified recombinant fragment of CK1 expressed in E. Coli.
Target Information
CNSK1A1 (CK1 alpha 1) is a member of the casein kinase I (CKI) gene family, which encodes serine/threonine kinases that preferentially phosphorylate acidic substrates. CKI proteins are monomeric, ranging from 25 to 55 kD, and are found in the nuclei, cytoplasm, and membrane fractions of eukaryotic cells. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Casein kinase I isoform alpha; CK I alpha; CK-I alpha; CK1; CKI alpha; CKI-alpha; clock regulator kinase; CSNK1A1; CSNK1A1/CK1; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; OTTHUMP00000224000; OTTHUMP00000224001; OTTHUMP00000224003; unnamed protein product; YIL035C
Gene Aliases: CK1; CK1a; CKIa; CSNK1A1; HEL-S-77p; HLCDGP1; PRO2975
UniProt ID: (Human) P48729
Entrez Gene ID: (Human) 1452
autophagosome assembly
protein phosphorylation
Golgi organization
signal transduction
cell surface receptor signaling pathway
negative regulation of autophagy
positive regulation of autophagy
Wnt signaling pathway
viral protein processing
regulation of Wnt signaling pathway
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
cellular response to nutrient levels
cellular response to nutrient
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of Rho protein signal transduction
TORC1 signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
NLRP3 inflammasome complex assembly
intermediate filament cytoskeleton organization
cell division
negative regulation of canonical Wnt signaling pathway
negative regulation of NLRP3 inflammasome complex assembly
positive regulation of NLRP3 inflammasome complex assembly
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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