Search
Invitrogen
ERK2 Monoclonal Antibody (4C11)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
MA5-15304
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
4C11
Immunogen
Purified recombinant fragment of human ERK2 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15304 targets ERK2 in indirect ELISA, IF, IHC, and WB applications and shows reactivity with Human, mouse, and Non-human primate samples.
The MA5-15304 immunogen is purified recombinant fragment of human ERK2 expressed in E. Coli.
MA5-15304 detects ERK2 which has a predicted molecular weight of approximately 41kDa.
Target Information
MAPK1 (ERK2) is a serine/threonine kinase that acts as an important activator of p90 RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: ERK-2; Erk2; cancer susceptibility protein; ERT1; Extracellular signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 1; MAPK 2; mitogen activated protein kinase 1; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; p42-MAPK; protein tyrosine kinase ERK2; unnamed protein product
Gene Aliases: 9030612K14Rik; AA407128; AU018647; C78273; ERK; ERK-2; ERK2; ERT1; Mapk; MAPK1; MAPK2; NS13; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2
UniProt ID: (Human) P28482, (Mouse) P63085
Entrez Gene ID: (Human) 5594, (Mouse) 26413
nucleotide binding
phosphotyrosine binding
DNA binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
kinase activity
transferase activity
phosphatase binding
identical protein binding
protein serine kinase activity
transcription factor binding
transferase activity, transferring phosphorus-containing groups
protein kinase binding
mitogen-activated protein kinase kinase kinase binding
non-receptor serine/threonine protein kinase
MAPK cascade
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
apoptotic process
chemotaxis
cellular response to DNA damage stimulus
signal transduction
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
chemical synaptic transmission
heart development
learning or memory
insulin receptor signaling pathway
organ morphogenesis
positive regulation of macrophage chemotaxis
positive regulation of peptidyl-threonine phosphorylation
neural crest cell development
Schwann cell development
peptidyl-threonine phosphorylation
cytosine metabolic process
regulation of ossification
regulation of cellular pH
thyroid gland development
regulation of protein stability
lipopolysaccharide-mediated signaling pathway
positive regulation of telomere maintenance
response to lipopolysaccharide
regulation of stress-activated MAPK cascade
mammary gland epithelial cell proliferation
cellular response to amino acid starvation
response to nicotine
intracellular signal transduction
ERBB signaling pathway
ERBB2-ERBB3 signaling pathway
outer ear morphogenesis
myelination
response to exogenous dsRNA
positive regulation of cholesterol biosynthetic process
negative regulation of cell differentiation
insulin-like growth factor receptor signaling pathway
thymus development
T cell receptor signaling pathway
B cell receptor signaling pathway
stress-activated MAPK cascade
regulation of cytoskeleton organization
Bergmann glial cell differentiation
long-term synaptic potentiation
face development
lung morphogenesis
trachea formation
labyrinthine layer blood vessel development
cardiac neural crest cell development involved in heart development
interleukin-34-mediated signaling pathway
chemokine-mediated signaling pathway
ERK1 and ERK2 cascade
response to epidermal growth factor
cellular response to tumor necrosis factor
caveolin-mediated endocytosis
regulation of Golgi inheritance
positive regulation of macrophage proliferation
positive regulation of neuroinflammatory response
regulation of early endosome to late endosome transport
MAPK import into nucleus
transcription, DNA-templated
cell cycle
response to toxic substance
phosphorylation
peptidyl-serine phosphorylation
sensory perception of pain
response to estrogen
positive regulation of translation
regulation of sequence-specific DNA binding transcription factor activity
cellular response to organic substance
cellular response to granulocyte macrophage colony-stimulating factor stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support