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Invitrogen
HCK Monoclonal Antibody (3D12E10)
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Product Details
MA5-15371
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3D12E10
Immunogen
Purified recombinant fragment of HCK expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15371 targets HCK in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.
The MA5-15371 immunogen is purified recombinant fragment of HCK expressed in E. Coli.
.
Target Information
Hematopoietic cell kinase (HCK) is a SRC-related kinase expressed in lymphoid and hematopoietic cells and may play a role in some forms of leukemia. (HCK Alias: DKFZp686D0638). HCK is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck; protein-tyrosine kinase; Tyrosine-protein kinase HCK; unnamed protein product
Gene Aliases: AIPCV; HCK; JTK9; p59Hck; p61Hck
UniProt ID: (Human) P08631
Entrez Gene ID: (Human) 3055
immune system process
leukocyte migration involved in immune response
innate immune response-activating signal transduction
negative regulation of inflammatory response to antigenic stimulus
protein phosphorylation
exocytosis
phagocytosis
response to stress
inflammatory response
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
integrin-mediated signaling pathway
mesoderm development
positive regulation of cell proliferation
regulation of cell shape
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
cell differentiation
positive regulation of actin filament polymerization
lipopolysaccharide-mediated signaling pathway
regulation of actin cytoskeleton organization
intracellular signal transduction
Fc-gamma receptor signaling pathway involved in phagocytosis
negative regulation of apoptotic process
leukocyte degranulation
innate immune response
respiratory burst after phagocytosis
protein autophosphorylation
regulation of inflammatory response
regulation of phagocytosis
defense response to Gram-positive bacterium
leukocyte migration
regulation of sequence-specific DNA binding transcription factor activity
interferon-gamma-mediated signaling pathway
cellular response to lipid
regulation of podosome assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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