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Invitrogen
JNK3 Monoclonal Antibody (10E4A4)
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Product Details
MA5-15403
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
10E4A4
Immunogen
Purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15403 targets MAPK10 in indirect ELISA, IF and WB applications and shows reactivity with Human and mouse samples.
The MA5-15403 immunogen is purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli.
MA5-15403 detects MAPK10 which has a predicted molecular weight of approximately 53kDa.
Target Information
MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). MAPK10 is involved in neuronal apoptosis and phosphorylates MAP2K4. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (NhpK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: c-Jun N-terminal kinase 3; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; mitogen activated protein kinase 10; Mitogen-activated protein kinase 10; OTTHUMP00000161181; OTTHUMP00000161183; OTTHUMP00000218718; SAPK/Erk/kinase 2; SAPK1b; stress activated protein kinase beta; Stress-activated protein kinase 1b; Stress-activated protein kinase JNK3; unnamed protein product
Gene Aliases: C230008H04Rik; JNK3; JNK3A; JNK3B1; JNK3B2; MAPK10; p493F12; p54bSAPK; PRKM10; SAPK(beta); SAPK1B; Serk2
UniProt ID: (Human) P53779, (Mouse) Q61831
Entrez Gene ID: (Human) 5602, (Mouse) 26414
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
JUN kinase activity
MAP kinase activity
MAP kinase kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
protein phosphorylation
signal transduction
JNK cascade
response to light stimulus
Fc-epsilon receptor signaling pathway
regulation of circadian rhythm
rhythmic process
cellular senescence
negative regulation of transcription from RNA polymerase II promoter
JUN phosphorylation
phosphorylation
locomotor rhythm
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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