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Invitrogen

Androgen Receptor Monoclonal Antibody (2H8)

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Product Details

MA5-15598

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2H8

Immunogen

Purified recombinant fragment of human AR expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10985750

Product Specific Information

MA5-15598 targets Androgen receptor in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.

The MA5-15598 immunogen is purified recombinant fragment of human AR expressed in E. Coli.

MA5-15598 detects Androgen receptor which has a predicted molecular weight of approximately 110kDa.

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Androgen receptor; androgen-receptor; AR-A; Dihydrotestosterone receptor; nuclear receptor; Nuclear receptor subfamily 3 group C member 4; nuclear receptor; AR3 is also known as AR-V7; RP11-383C12.1; splice variant 8; steroid hormone receptor; steroid hormone receptor; AR; Variant AR45

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Gene Aliases: AIS; AR; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM

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UniProt ID: (Human) P10275

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Entrez Gene ID: (Human) 367

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II general transcription initiation factor binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding steroid binding androgen binding protein binding beta-catenin binding zinc ion binding lipid binding enzyme binding estrogen response element binding sequence-specific DNA binding metal ion binding ATPase binding binding, bridging RNA polymerase II sequence-specific DNA binding transcription factor binding POU domain binding molecular condensate scaffold activity sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade in utero embryonic development regulation of systemic arterial blood pressure epithelial cell morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter signal transduction cell-cell signaling spermatogenesis single fertilization positive regulation of cell proliferation negative regulation of cell proliferation male gonad development fertilization gene expression regulation of gene expression positive regulation of gene expression male somatic sex determination intracellular estrogen receptor signaling pathway androgen receptor signaling pathway intracellular receptor signaling pathway positive regulation of intracellular estrogen receptor signaling pathway Leydig cell differentiation response to testosterone multicellular organism growth positive regulation of MAPK cascade positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of cell differentiation positive regulation of integrin biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase III promoter insulin-like growth factor receptor signaling pathway reproductive structure development regulation of developmental growth organ formation male genitalia morphogenesis epithelial cell proliferation negative regulation of epithelial cell proliferation prostate induction morphogenesis of an epithelial fold lateral sprouting involved in mammary gland duct morphogenesis regulation of prostatic bud formation prostate gland growth prostate gland epithelium morphogenesis epithelial cell differentiation involved in prostate gland development tertiary branching involved in mammary gland duct morphogenesis mammary gland alveolus development positive regulation of epithelial cell proliferation involved in prostate gland development reproductive system development cellular response to steroid hormone stimulus cellular response to estrogen stimulus cellular response to testosterone stimulus seminiferous tubule development membraneless organelle assembly positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of protein localization to plasma membrane negative regulation of extrinsic apoptotic signaling pathway
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