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Invitrogen
c-Rel Monoclonal Antibody (1E7)
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Product Details
MA5-15859
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E7
Immunogen
Purified recombinant fragment of human c-Rel expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15859 targets c-Rel in indirect ELISA, IF and IHC applications and shows reactivity with Human and mouse samples.
MA5-15859 targets c-Rel in WB against recombinant c-Rel and transfected cell lysates only.
The MA5-15859 immunogen is purified recombinant fragment of human c-Rel expressed in E. Coli.
MA5-15859 detects c-Rel which has a predicted molecular weight of approximately 78 kDa.
Target Information
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA., RELB (604758), NFKB1, and NFKB2. These proteins are related through a highly conserved N-terminal region termed the 'Rel domain, ' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (Belguise and Sonenshein, 2007).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BCD541; c-rel; C-Rel protein; C-Rel proto-oncogene protein; gemin 1; gemin-1; oncogene REL, avian reticuloendotheliosis; Proto-oncogene c-Rel; SMA; SMA1; SMA2; SMA3; SMA4; SMN; SMN2; SMNT; unnamed protein product; v-rel avian reticuloendotheliosis viral oncogene homolog
Gene Aliases: C-Rel; HIVEN86A; IMD92; REL
UniProt ID: (Human) Q04864
Entrez Gene ID: (Human) 5966, (Mouse) 19696
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
chromatin binding
Rel homology transcription factor
negative regulation of cytokine production
regulation of transcription, DNA-templated
inflammatory response
I-kappaB kinase/NF-kappaB signaling
negative regulation of gene expression
negative regulation of interferon-beta production
response to cytokine
NIK/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter
cytokine production
transcription, DNA-templated
transcription from RNA polymerase II promoter
positive regulation of interleukin-12 biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of neuron death
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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