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Invitrogen
gamma Catenin Monoclonal Antibody (4C12)
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FIGURE: 1 / 10
gamma Catenin Antibody (MA5-15905) in ICC/IF
Immunofluorescence analysis of gamma Catenin was performed using 70% confluent log phase HaCaT cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with gamma Catenin Monoclonal Antibody (4C12) (Product # MA5-15905) at 1:200 dilution in 0.1% BSA, incubated ... View More
Product Details
MA5-15905
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4C12
Immunogen
Purified recombinant fragment of human JUP expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15905 targets JUP in indirect ELISA, IF, IHC, and WB applications and shows reactivity with Human samples.
The MA5-15905 immunogen is purified recombinant fragment of human JUP expressed in E. Coli. .
MA5-15905 detects JUP which has a predicted molecular weight of approximately 82kDa.
Target Information
JUP is a major cytoplasmic protein which is the only known constituent common to sub membranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; Desmoplakin III; Desmoplakin-3; desmosomal protein 3; Junction plakoglobin; OTTHUMP00000164735
Gene Aliases: CTNNG; DP3; DPIII; JUP; PDGB; PG; PKGB
UniProt ID: (Human) P14923
Entrez Gene ID: (Human) 3728
transcription coactivator activity
structural molecule activity
protein binding
ligand-dependent nuclear receptor binding
protein phosphatase binding
protein homodimerization activity
alpha-catenin binding
cadherin binding
cell adhesion molecule binding
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
microtubule cortical anchor activity
positive regulation of cell-matrix adhesion
desmosome assembly
cell adhesion
cell migration
regulation of cell proliferation
positive regulation of protein import into nucleus
negative regulation of blood vessel endothelial cell migration
skin development
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
detection of mechanical stimulus
canonical Wnt signaling pathway
endothelial cell-cell adhesion
cellular response to indole-3-methanol
protein localization to plasma membrane
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
positive regulation of canonical Wnt signaling pathway
cell-cell adhesion
regulation of ventricular cardiac muscle cell action potential
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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