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Invitrogen
Chromogranin A Monoclonal Antibody (1A6B6)
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Product Details
MA5-17056
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A6B6
Immunogen
Purified recombinant fragment of human CHGA (amino acids: 87-252 ) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-17056 targets CHGA in indirect ELISA and WB applications and shows reactivity with Human and Mouse samples.
The MA5-17056 immunogen is purified recombinant fragment of human CHGA (amino acids: 87-252 ) expressed in E. Coli.
MA5-17056 detects CHGA which has a predicted molecular weight of approximately 50.7kDa.
Target Information
Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; chromofungin; chromogranin A; chromogranin A precursor; Chromogranin-A; CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; MGC105435; parathyroid secretory protein 1; Pituitary secretory protein I; SP-I; unnamed protein product
Gene Aliases: CGA; CHGA; ChrA; PHE5; PHES
UniProt ID: (Human) P10645, (Mouse) P26339
Entrez Gene ID: (Human) 1113, (Rat) 24258, (Mouse) 12652
regulation of the force of heart contraction
organelle organization
positive regulation of cAMP metabolic process
ovulation cycle
negative regulation of vasodilation
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
negative regulation of neuron death
mast cell chemotaxis
regulation of blood pressure
killing of cells of other organism
protein localization to secretory granule
negative regulation of catecholamine secretion
defense response to bacterium
mast cell degranulation
innate immune response
mast cell activation
negative regulation of insulin secretion
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
defense response to fungus
positive regulation of cardiac muscle contraction
adenylate cyclase-activating adrenergic receptor signaling pathway
positive regulation of relaxation of cardiac muscle
positive regulation of dense core granule biogenesis
mast cell cytokine production
adrenergic receptor signaling pathway involved in cardiac muscle relaxation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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