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Invitrogen
MMP3 Monoclonal Antibody (4F10)
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FIGURE: 1 / 5
MMP3 Antibody (MA5-17123) in WB
Western blot was performed using Anti-MMP3 Monoclonal Antibody (4F10), (Product # MA5-17123) and a 53.9 kDa band corresponding to MMP3 was observed in the cell lines. Whole cell extracts (30 µg lysate) of C8D1A (Lane 1), HeLa (Lane 2) and MDA-MB-231 (Lane 3) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary antibody (1:2000 dil... View More
Product Details
MA5-17123
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4F10
Immunogen
Purified recombinant fragment of human MMP3 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-17123 targets MMP3 in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17123 immunogen is purified recombinant fragment of human MMP3 expressed in E. Coli.
MA5-17123 detects MMP3 which has a predicted molecular weight of approximately 54kDa.
Target Information
MMP3 (stromelysin-1) belongs to the peptidase M10A subfamily. It is secreted in its pro-protein form, and is activated by extracellular proteinase cleavage. MMP3 is capable of binding to zinc and calcium ions, and has metallo-endopeptidase activity. The active enzyme degrades collagen, gelatin, fibronectin, and laminin. It is involved in normal cellular processes such as wound repair and tissue remodeling. Mutations in the gene can result in coronary heart disease 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 3.4.24.17; EMS-2; matrix metallo protease; matrix metalloproteinase 3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); Matrix metalloproteinase-3; MMP; MMP-3; MMPs; progelatinase; proteoglycanase; SL-1; stromelysin 1; Stromelysin-1; Stromelysin1; Transin-1; Transin1; unnamed protein product
Gene Aliases: CHDS6; MMP-3; MMP3; SL-1; SLN-1; SLN1; STMY; STMY1; STR-1; STR1
UniProt ID: (Human) P08254, (Mouse) P28862
Entrez Gene ID: (Human) 4314, (Mouse) 17392
immune system process
proteolysis
extracellular matrix disassembly
protein catabolic process
extracellular matrix organization
regulation of cell migration
collagen catabolic process
positive regulation of protein complex assembly
cellular response to reactive oxygen species
innate immune response
negative regulation of protein kinase B signaling
cellular response to lipopolysaccharide
cellular response to amino acid stimulus
cellular response to UV-A
cellular response to nitric oxide
regulation of neuroinflammatory response
response to amyloid-beta
negative regulation of reactive oxygen species metabolic process
negative regulation of hydrogen peroxide metabolic process
positive regulation of cell migration
positive regulation of protein oligomerization
positive regulation of oxidative stress-induced cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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