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Invitrogen
CAS Monoclonal Antibody (P5111)
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FIGURE: 1 / 5
CAS Antibody (MA5-18301) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of CAS was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: CAS Monoclonal Antibody (P5111) (Product # MA5-18301) diluted at 1:500. Red: phalloidin, a cytoskeleton marker. Scale bar = 10 µm.
Product Details
MA5-18301
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
P5111
Immunogen
Recombinant protein encompassing a sequence within the center region of human CSE1L. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2, Neuro2A, GL261, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12, PC-12, Rat2.
Predicted reactivity: Mouse (99%), Rat (100%), Zebrafish (95%), Xenopus laevis (97%), Pig (100%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCR/ABL fusion protein; BCR/ABL1 fusion; CAS; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; CSE1 chromosome segregation 1-like; epididymis secretory sperm binding protein; Exp2; Exportin-2; Importin-alpha re-exporter; MGC117283; MGC130036; MGC130037; putative Ran-binding domain; unnamed protein product
Gene Aliases: 2610100P18Rik; AA407533; Capts; CAS; CSE1; CSE1L; XPO2
UniProt ID: (Human) P55060, (Mouse) Q9ERK4
Entrez Gene ID: (Human) 1434, (Mouse) 110750, (Rat) 362273
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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