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Invitrogen
HIN-1 Monoclonal Antibody (3G5)
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Product Details
MA5-22866
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3G5
Immunogen
SCGB3A1 (AAH29176, 1 a.a. ~ 104 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide Sequence: MKLAALLGLC VALSCSSAAA FLVGSAKPVA QPVAALESAA EAGAGTLANP LGTLNPLKLL LSSLGIPVNH LIEGSQKCVA ELGPQAVGAV KALKALLGAL TVFG
Target Information
HIN-1, also known as High In Normal-1 or Secretoglobin Family 3A Member 1 (SCGB3A1), is a gene located on chromosome 5q33.3. It encodes a protein that is predominantly expressed in normal mammary epithelial cells and is thought to function in epithelial cell signaling, contributing to cellular differentiation and maintaining normal tissue architecture. The HIN-1 gene is often silenced or downregulated in various cancers, particularly breast cancer, due to hypermethylation of its promoter region, suggesting a potential tumor suppressor role. Loss of HIN-1 expression has been implicated in the progression of malignancies by disrupting normal cell signaling pathways, thereby facilitating oncogenesis. Given its significant downregulation in cancerous tissues, HIN-1 is being explored as a biomarker for early cancer detection and may provide insights into novel therapeutic strategies that aim to restore its expression and normal cellular functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytokine high in normal-1; Cytokine HIN-1; High in normal 1; high in normal-1 putative cytokine; Pneumo secretory protein 2; PnSP-2; Secretoglobin family 3A member 1; UGRP2MGC87867; Uteroglobin-related protein 2
Gene Aliases: HIN-1; HIN1; LU105; PnSP-2; PNSP2; SCGB3A1; UGRP2; UNQ629/PRO1245
UniProt ID: (Human) Q96QR1
Entrez Gene ID: (Human) 92304
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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