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Invitrogen
IL-22 Receptor alpha Monoclonal Antibody (305405)
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FIGURE: 1 / 4
IL-22 Receptor alpha Antibody (MA5-24017) in ICC/IF
Immunocytochemistry analysis of IL-22 Receptor alpha was detected in immersion fixed HT‚29 human colon adenocarcinoma cell line (positive) and HepG2 human hepatocellular carcinoma cell line (negative) cells. The cells were labeled with IL-22 Receptor alpha Mouse Monoclonal Antibody (Product # MA5-24017) using a dilution of 8 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™... View More
Product Details
MA5-24017
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
305405
Immunogen
CHO-derived recombinant human IL-22 R alpha 1 Pro18-Thr228
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-10, rhIL-22BP or rhIL-20 R alpha is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CRF2-9; cytokine receptor; Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; il-22 receptor; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; ILN; Interleukin; interleukin 22 receptor, alpha 1; Interleukin-22 receptor subunit alpha-1; unnamed protein product; ZcytoR11
Gene Aliases: CRF2-9; IL22R; IL22R1; IL22RA1
UniProt ID: (Human) Q8N6P7
Entrez Gene ID: (Human) 58985
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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