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Invitrogen
NLGN3 Monoclonal Antibody (566209)
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FIGURE: 1 / 1
NLGN3 Antibody (MA5-24253) in IHC (P)
Immunohistochemical analysis of NLGN3 in immersion fixed paraffin-embedded sections of human brain (cerebellum). Samples were incubated in NLGN3 monoclonal antibody (Product # MA5-24253) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary ... View More
Product Details
MA5-24253
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
566209
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Neuroligin 3 Gln38-Leu709
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
100% cross-reactivity with recombinant human (rh) Neuroligin 3 variant 2 and recombinant rat Neuroligin 3 variant 2 and no cross-reactivity with rhNeuroligin 1 variant 2, rhNeuroligin 2, rhNeuroligin 4, recombinant rat Neuroligin 1, 1 variant 2, 2 variant 2, or 3 variant 4 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ASPGX1; AUTSX1; Gliotactin homolog; Neuroligin-3; unnamed protein product
Gene Aliases: HNL3; KIAA1480; NL3; NLGN3
UniProt ID: (Human) Q9NZ94
Entrez Gene ID: (Human) 54413
regulation of respiratory gaseous exchange by neurological system process
receptor-mediated endocytosis
cell adhesion
neuron cell-cell adhesion
chemical synaptic transmission
synapse assembly
learning
adult behavior
social behavior
synaptic vesicle endocytosis
axon extension
modulation of synaptic transmission
synapse organization
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
rhythmic synaptic transmission
inhibitory postsynaptic potential
vocalization behavior
postsynaptic membrane assembly
presynaptic membrane assembly
presynapse assembly
positive regulation of glutamate receptor signaling pathway
positive regulation of excitatory postsynaptic potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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