Search
Invitrogen
CLEC12A Monoclonal Antibody (687317)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 1
CLEC12A Antibody (MA5-24312) in Flow
Flow cytometric analysis of CLEC12A in Human peripheral blood (filled histogram) vs isotype control antibody (open histogram) granulocytes using CLEC12A Monoclonal Antibody (Product # MA5-24312). Followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody.
Product Details
MA5-24312
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
687317
Immunogen
Mouse myeloma cell line NS0-derived recombinant human MICL/CLEC12A Thr67-Ala265
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
CD371 is also known as Clec12A or Myeloid Inhibitory C-type Lectin-like receptor (MICL). CD371 is a highly glycosylated transmembrane receptor with a cytoplasmic ITIM that associates with SHP1 and SHP2. CD371 is expressed mainly on granulocytes, monocytes, macrophages, and dendritic cells, including plasmacytoid dendritic cells. Expression of CD371 on NK cells remains controversial. Although the function of CD371 is not fully understood, studies suggest that this receptor plays a role in inflammation and LPS activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: C-type lectin domain family 12 member A; C-type lectin protein CLL-1; C-type lectin superfamily; C-type lectin-like molecule 1; C-type lectin-like molecule-1; CD371; CLL-1; DCAL-2; Dendritic cell-associated lectin 2; hKLRL1; Killer cell C-type lectin-like receptor L1; MICL; MICL-alpha; type II transmembrane protein; MICL-beta; type II transmembrane protein; MICL-gamma; type II transmembrane protein; Myeloid inhibitory C-type lectin-like receptor; unnamed protein product
Gene Aliases: CD371; CLEC12A; CLL-1; CLL1; DCAL-2; DCAL2; hKLRL1; KLRL1; MICL
UniProt ID: (Human) Q5QGZ9
Entrez Gene ID: (Human) 160364
neutrophil activation involved in immune response
signal transduction
positive regulation of type I interferon production
negative regulation of natural killer cell activation
negative regulation of inflammatory response
negative regulation of immune response
negative regulation of neutrophil activation
negative regulation of dendritic cell differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support