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Invitrogen
PTCH Monoclonal Antibody (OTI5C7)
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Product Details
MA5-24893
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI5C7
Immunogen
Human recombinant protein fragment corresponding to amino acids 122-436 of PTCH1 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: etID309849.2; FLJ26746; FLJ42602; HGNC:9585; OTTHUMP00000021709; OTTHUMP00000021710; patched; patched gene homolog; similar to Drosophila patched protein, Swiss-Prot Accession Number P18502; transmembrane protein; Method: conceptual translation supplied by author; patched1; Protein patched homolog 1; PTC; ptc-1; PTCH protein -3; RP11-435O5.3; unnamed protein product
Gene Aliases: BCNS; BCNS1; NBCCS; PTC; PTC1; PTCH; PTCH1; SLC65B1
UniProt ID: (Human) Q13635
Entrez Gene ID: (Human) 5727
negative regulation of transcription from RNA polymerase II promoter
branching involved in ureteric bud morphogenesis
in utero embryonic development
cell fate determination
neural tube formation
neural tube closure
heart morphogenesis
signal transduction
spermatid development
regulation of mitotic cell cycle
pattern specification process
brain development
negative regulation of cell proliferation
epidermis development
regulation of smoothened signaling pathway
response to xenobiotic stimulus
response to mechanical stimulus
organ morphogenesis
dorsal/ventral pattern formation
epidermal cell fate specification
response to chlorate
negative regulation of keratinocyte proliferation
positive regulation of cholesterol efflux
protein processing
spinal cord motor neuron differentiation
neural tube patterning
dorsal/ventral neural tube patterning
neural plate axis specification
embryonic limb morphogenesis
prostate gland development
mammary gland development
response to estradiol
response to retinoic acid
regulation of protein localization
limb morphogenesis
hindlimb morphogenesis
regulation of growth
negative regulation of multicellular organism growth
regulation of cell proliferation
glucose homeostasis
response to alkaloid
keratinocyte proliferation
positive regulation of epidermal cell differentiation
negative regulation of osteoblast differentiation
negative regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
embryonic organ development
smooth muscle tissue development
epithelial cell proliferation
negative regulation of epithelial cell proliferation
negative regulation of cell division
pharyngeal system development
mammary gland duct morphogenesis
mammary gland epithelial cell differentiation
cell differentiation involved in kidney development
somite development
cellular response to cholesterol
commissural neuron axon guidance
stem cell proliferation
cell proliferation involved in metanephros development
metanephric collecting duct development
protein localization to plasma membrane
liver regeneration
negative regulation of stem cell proliferation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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