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Invitrogen
Kindlin 2 Monoclonal Antibody (OTI25A4)
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Product Details
MA5-24940
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI25A4
Immunogen
Full-length protein expressed in 293T cell transfected with human FERMT2 expression vector
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fermitin family homolog 2; fermitin family member 2; kindlin 2; Kindlin-2; MIG-2; mitogen inducible gene 2 protein; mitogen inducible gene-2; Mitogen-inducible gene 2 protein; PH domain-containing family C member 1; pleckstrin homology domain containing, family C (with FERM domain) member 1; pleckstrin homology domain containing, family C member 1; Pleckstrin homology domain-containing family C member 1; unnamed protein product
Gene Aliases: FERMT2; KIND2; mig-2; MIG2; PLEKHC1; UNC112; UNC112B
UniProt ID: (Human) Q96AC1
Entrez Gene ID: (Human) 10979
actin binding
integrin binding
protein binding
phosphatidylinositol-3,4,5-trisphosphate binding
lipid binding
protein kinase binding
type I transforming growth factor beta receptor binding
protein serine/threonine kinase activator activity
SMAD binding
actin filament binding
protein serine/threonine kinase binding
cell adhesion
cell-matrix adhesion
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
regulation of cell shape
positive regulation of epithelial to mesenchymal transition
Wnt signaling pathway
regulation of cell morphogenesis
positive regulation of cell migration
integrin activation
positive regulation of integrin activation
adherens junction maintenance
substrate adhesion-dependent cell spreading
positive regulation of Rho protein signal transduction
negative regulation of vascular permeability
negative regulation of fat cell differentiation
positive regulation of osteoblast differentiation
focal adhesion assembly
positive regulation of stress fiber assembly
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
limb development
positive regulation of ERK1 and ERK2 cascade
protein localization to membrane
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of protein localization to nucleus
protein localization to cell junction
positive regulation of mesenchymal stem cell proliferation
positive regulation of wound healing, spreading of epidermal cells
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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