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Invitrogen
Cytochrome P450 Reductase Monoclonal Antibody (OTI3F10)
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FIGURE: 1 / 17
Cytochrome P450 Reductase Antibody (MA5-24977) in ICC/IF
Immunofluorescence analysis of NADPH--cytochrome P450 reductase was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Cytochrome P450 Reductase Monoclonal Antibody (OTI3F10) (Product # MA5-24977) at 1:100... View More
Product Details
MA5-24977
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI3F10
Immunogen
Full length human recombinant protein of POR produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCR; CPR; CY DKFZp686G04235; DKFZp686G04235; FLJ26468; NADPH Cytochrome; NADPH--cytochrome P450 reductase; NADPH--hemoprotein reductase; NADPH-dependent cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; P450 Reductase; unnamed protein product
Gene Aliases: CPR; CYPOR; P450R; POR
UniProt ID: (Human) P16435
Entrez Gene ID: (Human) 5447
NADPH-hemoprotein reductase activity
cytochrome-b5 reductase activity, acting on NAD(P)H
protein binding
enzyme activator activity
nitric oxide dioxygenase activity
electron carrier activity
FMN binding
oxidoreductase activity
hydrolase activity
enzyme binding
iron-cytochrome-c reductase activity
flavin adenine dinucleotide binding
NADP binding
xenobiotic metabolic process
nitric oxide biosynthetic process
response to nutrient
response to xenobiotic stimulus
carnitine metabolic process
response to hormone
flavonoid metabolic process
fatty acid oxidation
electron transport chain
positive regulation of chondrocyte differentiation
negative regulation of apoptotic process
nitrate catabolic process
positive regulation of smoothened signaling pathway
nitric oxide catabolic process
positive regulation of growth plate cartilage chondrocyte proliferation
demethylation
cellular response to gonadotropin stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to peptide hormone stimulus
response to dexamethasone
positive regulation of steroid hormone biosynthetic process
cellular organofluorine metabolic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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