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Invitrogen
ERK5 Monoclonal Antibody (OTI3H2)
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Product Details
MA5-25341
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3H2
Immunogen
Full length human recombinant protein of MAPK7 produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Amount
60 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK7 is activated by mitogen-activated protein kinase 5 (MAP2K5/MEK5) and is involved in downstream signaling processes of various receptors. In response to extracelluar signals, MAPK7 translocates to the cell nucleus where it regulates gene expression by phosphorylating and activating different transcription factors. Gene deletion of MAPK7 in mice results in defective blood vessel and cardiac development leading to embryonic lethality. MAPK7 has been shown to be critical for endothelial function and maintenance of blood vessel integrity. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. ERK5 is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Big MAP kinase 1; BMK-1; BMK1 kinase; BNhp-1; BNhp1 kinase; ERK-5; extracellular signal regulated kinase 5; Extracellular signal-regulated kinase 5; extracellular-signal-regulated kinase 5; MAP kinase 7; MAPK 7; MAPK7-T; mitogen activated protein kinase 7; Mitogen-activated protein kinase 7; unnamed protein product
Gene Aliases: BMK-1; BMK1; ERK-5; ERK4; ERK5; Erk5-T; MAPK7; PRKM7
UniProt ID: (Human) Q13164, (Mouse) Q9WVS8
Entrez Gene ID: (Human) 5598, (Mouse) 23939
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase activity
enzyme inhibitor activity
protein binding
ATP binding
kinase activity
transferase activity
mitogen-activated protein kinase binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
signal transduction
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cell differentiation
calcineurin-NFAT signaling cascade
cellular response to stress
negative regulation of heterotypic cell-cell adhesion
negative regulation of smooth muscle cell apoptotic process
intracellular signal transduction
negative regulation of apoptotic process
regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
negative regulation of inflammatory response
positive regulation of protein metabolic process
negative regulation of response to cytokine stimulus
cellular response to hydrogen peroxide
negative regulation of calcineurin-NFAT signaling cascade
cellular response to growth factor stimulus
cellular response to laminar fluid shear stress
cellular response to transforming growth factor beta stimulus
intracellular signaling cassette
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of endothelial cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
protein phosphorylation
cell cycle
phosphorylation
peptidyl-serine phosphorylation
positive regulation of transcription from RNA polymerase II promoter in response to stress
negative regulation of NFAT protein import into nucleus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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